1775-37-7

Usage

Uses

Used in Pharmaceutical Industry:
N-[4-(4-nitrophenyl)sulfonylphenyl]acetamide is used as a key intermediate in the synthesis of the Daspone metabolite for its potential therapeutic applications. Its unique chemical properties enable it to be a valuable component in the development of new drugs and pharmaceuticals, particularly those targeting specific metabolic pathways or conditions.

InChI:InChI=1/C14H12N2O5S/c1-10(17)15-11-2-6-13(7-3-11)22(20,21)14-8-4-12(5-9-14)16(18)19/h2-9H,1H3,(H,15,17)

Upstream product

• 7467-51-8 4-acetylamino-4'-nitrodiphenyl sulfide 
• 101533-62-4 1-[4-(4-nitro-benzenesulfonyl)-phenyl]-ethanone 
• 1948-92-1 4-(4-nitrophenylsulfonyl)aniline 
• 108-24-7 acetic anhydride 
• 103-84-4 Acetanilid 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 710-24-7 4-acetamidobenzenesulfinic acid 
• 586-78-7 para-nitrophenyl bromide 
• 15898-43-8 sodium 4-acetamidobenzenesulfinate 
• 100-00-5 4-chlorobenzonitrile 
• 101-59-7 4-amino-4'-nitrodiphenyl sulfide 
• 122-80-5 N-acetyl-p-phenylenediamine 
• 13113-79-6 sodium 4-nitrobenzenethiolate 
• 1126-81-4 4-acetamidothiophenol 

Downstream Products

• 101289-23-0 acetic acid-[4-(N-ethyl-sulfanilyl)-anilide] 
• 77-46-3 acedapsone 
• 1948-92-1 4-(4-nitrophenylsulfonyl)aniline 
• 565-20-8 monoacetyldapsone 
• 32604-86-7 monoacetyldapsone hydroxylamine 
• 51224-82-9 acetic acid-[2-nitro-4-(4-nitro-benzenesulfonyl)-anilide] 
• 80-08-0 dapsone 
• 84907-42-6 sulfanilic acid-(4-sulfanilyl-anilide) 
• 36679-48-8 [4-(acetoxy-acetyl-amino)-phenyl]-(4-acetylamino-phenyl)-sulfone 
• 50444-11-6 bis-[4-(N-acetyl-sulfanilyl)-phenyl]-diazene-N-oxide 
• 22969-57-9 acetic acid-[4-(4-trans-cinnamylidenamino-benzenesulfonyl-)-anilide] 
• 51688-42-7 4-N-Acetyl-N-ethylamino-4'-nitro-diphenylsulfon 
• 51688-44-9 N,N-diethyl-4-((4-nitrophenyl)sulfonyl)aniline 
• 60515-93-7 N-acetyl-sulfanilic acid-[4-(4-nitro-benzenesulfonyl)-anilide] 

Relevant academic research and scientific papers

PROCESS FOR SYNTHESIS OF 4-4'-DIAMINO-DIPHENYL-SULFONE

A new process for the preparation and purification of 4-4'-diamino-diphenyl-sulfone (dapsone) is described. The process described is a three step process comprising a condensation reaction with the synthesis of a thioeter intermediate and then steps of oxidation and reduction in suitable conditions in order to obtain a product with good yield and purity.

Studies on 2,3,N,N'-substituted 4,4'-diaminodiphenylsulfones as potential antimalarial agents

A series of new 4,4'-diaminodiphenylsulfones substituted at 2 and 3 position and also at primary amino group of the phenyl rings have been synthesised and evaluated for their antimalarial activity against Plasmodium berghei infection in mice. Some of these compounds were active and showed complete inhibition of parasitaemia which included 7a1-7a4, 7b3, 7b4 and 16a at 1 mg/kg i.p. for 4 days and 16a, at 0.3 mg/kg for 4 days. Some compounds tested for their synthetase inhibitory action in cell-free system isolated from P. berghei (7b1, 7b2 and 8b2) were found to be more active than diaminodiphenylsulphone. The difference in order of activity between these in vivo and in vitro tests may be due to differences in their pharmacokinetic properties.