3-(6-amino-5-(1-(2,6-dichlorophenyl)ethoxy)pyridin-3-yl)-5,6,7,8-tetrahydro-1, 6-naphthyridin-8-ol

Base Information

Chemical Name:3-(6-amino-5-(1-(2,6-dichlorophenyl)ethoxy)pyridin-3-yl)-5,6,7,8-tetrahydro-1, 6-naphthyridin-8-ol
CAS No.:1613148-61-0
Molecular Formula:C₂₁H₂₀Cl₂N₄O₂
Molecular Weight:431.321
Hs Code.:

Synonyms:3-(6-amino-5-(1-(2,6-dichlorophenyl)ethoxy)pyridin-3-yl)-5,6,7,8-tetrahydro-1, 6-naphthyridin-8-ol

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Chemical Property of 3-(6-amino-5-(1-(2,6-dichlorophenyl)ethoxy)pyridin-3-yl)-5,6,7,8-tetrahydro-1, 6-naphthyridin-8-ol

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Technology Process of 3-(6-amino-5-(1-(2,6-dichlorophenyl)ethoxy)pyridin-3-yl)-5,6,7,8-tetrahydro-1, 6-naphthyridin-8-ol

There total 9 articles about 3-(6-amino-5-(1-(2,6-dichlorophenyl)ethoxy)pyridin-3-yl)-5,6,7,8-tetrahydro-1, 6-naphthyridin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.6%

: 1613148-66-5
3-(6-(bis(tert-butoxycarbonyl)amino)-5-(1-(2,6-dichlorophenyl)ethoxy)pyridin-3-yl)-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-8-ol

: 1613148-61-0
3-(6-amino-5-(1-(2,6-dichlorophenyl)ethoxy)pyridin-3-yl)-5,6,7,8-tetrahydro-1, 6-naphthyridin-8-ol

Guidance literature:: With hydrogenchloride; In dichloromethane; ethyl acetate; at 0 - 20 ℃;

Reference yield:

: 1184950-48-8
3-bromo-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

: 1613148-61-0
3-(6-amino-5-(1-(2,6-dichlorophenyl)ethoxy)pyridin-3-yl)-5,6,7,8-tetrahydro-1, 6-naphthyridin-8-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

2: trifluoroacetic anhydride / dichloromethane / 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / water; 1,2-dimethoxyethane / 95 °C / Inert atmosphere

4: hydrogenchloride / dichloromethane; ethyl acetate / 0 - 20 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate;

Reference yield:

: 3-bromo-8-oxo-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

: 1613148-61-0
3-(6-amino-5-(1-(2,6-dichlorophenyl)ethoxy)pyridin-3-yl)-5,6,7,8-tetrahydro-1, 6-naphthyridin-8-ol

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic anhydride / dichloromethane / 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / water; 1,2-dimethoxyethane / 95 °C / Inert atmosphere

3: hydrogenchloride / dichloromethane; ethyl acetate / 0 - 20 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; trifluoroacetic anhydride; In 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate;