Technology Process of 3-(6-(bis(tert-butoxycarbonyl)amino)-5-(1-(2,6-dichlorophenyl)ethoxy)pyridin-3-yl)-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-8-ol
There total 12 articles about 3-(6-(bis(tert-butoxycarbonyl)amino)-5-(1-(2,6-dichlorophenyl)ethoxy)pyridin-3-yl)-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-8-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate;
In
1,2-dimethoxyethane; water;
at 95 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C
1.2: 20 °C
2.1: iron; 3,3,5-Tribromo-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one / 1 h / 100 °C
3.1: N-Bromosuccinimide / acetonitrile / 3 h / 0 °C
4.1: dmap / N,N-dimethyl-formamide / 20 °C
5.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide / 80 °C / Inert atmosphere
6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate / 1,2-dimethoxyethane; water / 95 °C / Inert atmosphere
With
dmap; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; iron; sodium hydride; caesium carbonate; 3,3,5-Tribromo-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;
In
tetrahydrofuran; 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
2: trifluoroacetic acid / methanol; chloroform / 20 °C
3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate / 1,2-dimethoxyethane; water / 95 °C / Inert atmosphere
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
methanol; 1,2-dimethoxyethane; dichloromethane; chloroform; water;
