6-[[3-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl]methoxy]-2(1H)-quinolinone

Base Information

Chemical Name:6-[[3-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl]methoxy]-2(1H)-quinolinone
CAS No.:253273-91-5
Molecular Formula:C₁₉H₁₅N₃O₃
Molecular Weight:333.346
Hs Code.:
DSSTox Substance ID:DTXSID701154059

Synonyms:SCHEMBL7424878;DTXSID701154059;6-[[3-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl]methoxy]-2(1H)-quinolinone;253273-91-5

Suppliers and Price of 6-[[3-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl]methoxy]-2(1H)-quinolinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-[[3-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl]methoxy]-2(1H)-quinolinone

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:333.11134135
Heavy Atom Count:25
Complexity:512

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=NC(=NO1)C2=CC=CC(=C2)COC3=CC4=C(C=C3)NC(=O)C=C4

Technology Process of 6-[[3-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl]methoxy]-2(1H)-quinolinone

There total 2 articles about 6-[[3-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl]methoxy]-2(1H)-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.5%

: 19315-93-6
6-hydroxy-1H-quinolin-2-one

: 253273-90-4
3-[3-(bromomethyl)phenyl]-5-methyl-1,2,4-oxadiazole

: 253273-91-5
6-[3-(5-methyl-1,2,4-oxadiazol-2-yl)-benzyloxy]-1,2-dihydroquinolin-2-one

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 10 - 20 ℃; for 2h;
DOI:10.1016/S0040-4020(99)00752-8

Reference yield:

: 87944-75-0
5-Methyl-3-(m-tolyl)-1,2,4-oxadiazole

: 253273-91-5
6-[3-(5-methyl-1,2,4-oxadiazol-2-yl)-benzyloxy]-1,2-dihydroquinolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 52.4 percent / NBS / CCl₄ / 2 h / Irradiation; reflux

2: 24.5 percent / t-BuOK / dimethylformamide / 2 h / 10 - 20 °C

With N-Bromosuccinimide; potassium tert-butylate; In tetrachloromethane; N,N-dimethyl-formamide; 1: Bromination / 2: Condensation;
DOI:10.1016/S0040-4020(99)00752-8

Reference yield: 76.0%

: 150255-96-2
(3‐cyanophenyl)boronic acid

: 253273-91-5
6-[3-(5-methyl-1,2,4-oxadiazol-2-yl)-benzyloxy]-1,2-dihydroquinolin-2-one

: 3-{6-[3-(5-methyl-1,2,4-oxadiazol-2-yl)-benzyloxy]-2-oxo-2H-quinolin-1-yl}-benzonitrile

Guidance literature:: With copper diacetate; 4 A molecular sieve; triethylamine; In pyridine; dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/S0040-4020(99)00752-8