87944-75-0Relevant academic research and scientific papers
Rh(iii)-Catalyzed cascade annulation to produce an N-acetyl chain of spiropyrroloisoquinoline derivatives
Dong, Lin,He, Yuan,Zheng, Jing
supporting information, p. 2293 - 2299 (2022/04/07)
A new rhodium(iii)-catalyzed multistep cascade spirocyclization approach was developed to synthesize a novel N-acetyl chain of spiropyrroloisoquinoline derivatives using oxadiazoles as the directing group. This one-pot reaction also isolates aryloxadiazole derivatives as cross-coupling intermediates. This simple approach could efficiently expand the scope of the skeletons of isoquinolines and aryloxadiazoles.
Efficient Synthesis of Functionalized Indene Derivatives via Rh(III)-Catalyzed Cascade Reaction between Oxadiazoles and Allylic Alcohols
Zhang, Jing,Sun, Jun-Shu,Xia, Ying-Qi,Dong, Lin
supporting information, p. 2037 - 2041 (2019/03/28)
A highly efficient rhodium(III)-catalyzed synthesis of novel functionalized indene derivatives has been achieved via C?H activation/intramolecular aldol condensation. This cascade reaction is an atom economical protocol which could be further applied to build more complex compounds. (Figure presented.).
Cobalt(III)-Catalyzed Oxadiazole-Directed C-H Activation for the Synthesis of 1-Aminoisoquinolines
Yang, Fan,Yu, Jiaojiao,Liu, Yun,Zhu, Jin
supporting information, p. 2885 - 2888 (2017/06/07)
Aromatic heterocycles have been identified as effective directing groups (DGs) in C-H functionalization but can be retained as undesired bulky substituents in the final products. Herein, we report a Co(III)-catalyzed 1-aminoisoquinoline synthesis strategy based on oxadiazole-directed aromatic C-H coupling with alkynes and a subsequent redox-neutral C-N cyclization reaction. This labile N-O bond-based protocol has allowed the toleration of a broad range of functional groups.
A novel, one-pot, three-component synthesis of 1,2,4-oxadiazoles under microwave irradiation and solvent-free conditions
Adib, Mehdi,Mahdavi, Mohammad,Mahmoodi, Niusha,Pirelahi, Hooshang,Bijanzadeh, Hamid Reza
, p. 1765 - 1767 (2008/02/04)
A novel synthesis of 3,5-disubstituted 1,2,4-oxadiazoles is described from a one-pot, three-component reaction between nitriles, hydroxylamine, and Meldrum's acids under microwave irradiation and solvent-free conditions in good to excellent yields. Georg
Synthesis of 3,5-disubstituted-1,2,4-oxadiazoles using tetrabutylammonium fluoride as a mild and efficient catalyst
Gangloff, Anthony R.,Litvak, Joane,Shelton, Emma J.,Sperandio, David,Wang, Vivian R.,Rice, Kenneth D.
, p. 1441 - 1443 (2007/10/03)
Tetrabutylammonium fluoride (TBAF) was found to be a mild and efficient catalyst for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles. Using 0.1 - 1.0 equivalents of TBAF in THF for 1 - 24 h at room temperature, alkanoyl- and aroyloxyamidines were converted in high yield to the corresponding 3,5-disubstituted-1,2,4-oxadiazoles. A variety of R and R′ substituents were investigated.
THERMAL REACTIONS OF ARYLAMIDOXIMES
Leite, Lucia F. C. da Costa,Srivastava, Rajendra M.,Cavalcanti, Alexandre P.
, p. 203 - 210 (2007/10/02)
The effect of heat on arylamidoximes, 1a-g, has been examined.When acetic acid was used as solvent, amidoximes, 1a-g, provided three products, viz., 3,5-bis-aryl-1,2,4-oxadiazoles, 2a-g, 3-aryl-5-methyl-1,2,4-oxadiazoles, 3a-g, and a small quantity of an
SYNTHESIS AND SPECTROSCOPIC STUDIES OF 5-METHYL-3-PHENYL- AND 5-METHYL-3-(o-, m-, AND p-TOLYL)-1,2,4-OXADIAZOLES.
Srivastava,Mendes e Silva
, p. 221 - 223 (2007/10/02)
Preparation of four 1,2,4-oxadiazoles, 2a-d, from O-acetyl derivatives of benzamidoximes, 1a-d, are reported. Two of them, viz. , 2b,c, were not encountered in the literature. Spectroscopic studies (IR, UV, and **1H NMR) were carried out to learn more abo
