3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-((5-methylisoxazol-3-yl)methyl)-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-((5-methylisoxazol-3-yl)methyl)-1H-pyrazole-5-carboxamide
CAS No.:1282606-53-4
Molecular Formula:C₁₉H₁₉FN₆O₃
Molecular Weight:398.397
Hs Code.:

Synonyms:3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-((5-methylisoxazol-3-yl)methyl)-1H-pyrazole-5-carboxamide

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Chemical Property of 3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-((5-methylisoxazol-3-yl)methyl)-1H-pyrazole-5-carboxamide

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Technology Process of 3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-((5-methylisoxazol-3-yl)methyl)-1H-pyrazole-5-carboxamide

There total 5 articles about 3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-((5-methylisoxazol-3-yl)methyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₇FN₆O₄

: 1282606-53-4
3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-((5-methylisoxazol-3-yl)methyl)-1H-pyrazole-5-carboxamide

Guidance literature:: C₂₇H₂₇FN₆O₄; With trifluorormethanesulfonic acid; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In water; at 0 ℃;

Reference yield:

: 1282606-70-5
methyl 3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

: 1282606-53-4
3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-((5-methylisoxazol-3-yl)methyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol / 1 h / Reflux

1.2: pH 1 - 2

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 72 h / 20 °C

3.1: trifluoroacetic acid; trifluorormethanesulfonic acid / dichloromethane / 2 h / 20 °C

3.2: 0 °C

With trifluorormethanesulfonic acid; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 1282606-66-9
methyl 1-(4-methoxybenzyl)-3-(2-oxoimidazolidin-1-yl)-1H-pyrazole-5-carboxylate

: 1282606-53-4
3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-((5-methylisoxazol-3-yl)methyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / acetone / 32 h / Reflux

2.1: sodium hydroxide / ethanol / 1 h / Reflux

2.2: pH 1 - 2

3.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 72 h / 20 °C

4.1: trifluoroacetic acid; trifluorormethanesulfonic acid / dichloromethane / 2 h / 20 °C

4.2: 0 °C

With trifluorormethanesulfonic acid; benzotriazol-1-ol; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; acetone;