methyl 3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

Base Information

Chemical Name:methyl 3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate
CAS No.:1282606-70-5
Molecular Formula:C₂₃H₂₃FN₄O₄
Molecular Weight:438.458
Hs Code.:

Synonyms:methyl 3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

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Chemical Property of methyl 3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

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Technology Process of methyl 3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

There total 5 articles about methyl 3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1282606-66-9
methyl 1-(4-methoxybenzyl)-3-(2-oxoimidazolidin-1-yl)-1H-pyrazole-5-carboxylate

: 459-46-1
4-Fluorobenzyl bromide

: 1282606-70-5
methyl 3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

Guidance literature:: With caesium carbonate; In acetone; for 32h; Reflux;

Reference yield:

: 625386-10-9
2-(4-methoxybenzyl)-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester

: 1282606-70-5
methyl 3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

4: caesium carbonate / acetone / 32 h / Reflux

With hydrogen; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: 181585-93-3
5-nitro-2H-pyrazole-3-carboxylic acid methyl ester

: 1282606-70-5
methyl 3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / tetrahydrofuran / 2 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

5: caesium carbonate / acetone / 32 h / Reflux

With hydrogen; sodium hydride; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; mineral oil;