2-{9-[(1R)-1-methyl-2-(benzyloxy)ethyl]-(9S,7R)-6,10-dioxaspiro[4.5]dec-7-yl}-N-methoxy-N-methylacetamide

Base Information

Chemical Name:2-{9-[(1R)-1-methyl-2-(benzyloxy)ethyl]-(9S,7R)-6,10-dioxaspiro[4.5]dec-7-yl}-N-methoxy-N-methylacetamide
CAS No.:609828-36-6
Molecular Formula:C₂₂H₃₃NO₅
Molecular Weight:391.508
Hs Code.:

Synonyms:2-{9-[(1R)-1-methyl-2-(benzyloxy)ethyl]-(9S,7R)-6,10-dioxaspiro[4.5]dec-7-yl}-N-methoxy-N-methylacetamide

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Chemical Property of 2-{9-[(1R)-1-methyl-2-(benzyloxy)ethyl]-(9S,7R)-6,10-dioxaspiro[4.5]dec-7-yl}-N-methoxy-N-methylacetamide

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Technology Process of 2-{9-[(1R)-1-methyl-2-(benzyloxy)ethyl]-(9S,7R)-6,10-dioxaspiro[4.5]dec-7-yl}-N-methoxy-N-methylacetamide

There total 5 articles about 2-{9-[(1R)-1-methyl-2-(benzyloxy)ethyl]-(9S,7R)-6,10-dioxaspiro[4.5]dec-7-yl}-N-methoxy-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89046-67-3
(2S,3R)-2-methyl-1-(phenylmethoxy)hex-5-en-3-ol

: 609828-36-6
2-{9-[(1R)-1-methyl-2-(benzyloxy)ethyl]-(9S,7R)-6,10-dioxaspiro[4.5]dec-7-yl}-N-methoxy-N-methylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 99 percent / imidazole / CH₂Cl₂ / 3 h

2.1: O₃ / CH₂Cl₂ / -78 °C

2.2: triphenylphosphine / CH₂Cl₂ / -78 - 20 °C

2.3: 86 percent / CH₂Cl₂ / 6 h / Heating

3.1: 76 percent / potassium hexamethyldisilazide / tetrahydrofuran / 1.17 h / 0 °C

4.1: zinc(II) triflate; sodium bicarbonate; EtSH / CH₂Cl₂ / 20 h

5.1: 496 mg / PPTS / CH₂Cl₂ / 14 h

With 1H-imidazole; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; zinc trifluoromethanesulfonate; sodium hydrogencarbonate; ozone; ethanethiol; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja027638q

Reference yield:

: 609828-32-2
(2E)-(6S,5R)-5-hydroxy-N-methoxy-6-methyl-N-methyl-7-(phenylmethoxy)hept-2-enamide

: 609828-36-6
2-{9-[(1R)-1-methyl-2-(benzyloxy)ethyl]-(9S,7R)-6,10-dioxaspiro[4.5]dec-7-yl}-N-methoxy-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / potassium hexamethyldisilazide / tetrahydrofuran / 1.17 h / 0 °C

2: zinc(II) triflate; sodium bicarbonate; EtSH / CH₂Cl₂ / 20 h

3: 496 mg / PPTS / CH₂Cl₂ / 14 h

With pyridinium p-toluenesulfonate; potassium hexamethylsilazane; zinc trifluoromethanesulfonate; sodium hydrogencarbonate; ethanethiol; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja027638q

Reference yield:

: 609828-68-4
1-{(1R)1-[(1S)-1-methyl-2-(phenylmethoxy)ethyl]but-3-enyloxy}-1,1-diethyl-1-silapropane

: 609828-36-6
2-{9-[(1R)-1-methyl-2-(benzyloxy)ethyl]-(9S,7R)-6,10-dioxaspiro[4.5]dec-7-yl}-N-methoxy-N-methylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: O₃ / CH₂Cl₂ / -78 °C

1.2: triphenylphosphine / CH₂Cl₂ / -78 - 20 °C

1.3: 86 percent / CH₂Cl₂ / 6 h / Heating

2.1: 76 percent / potassium hexamethyldisilazide / tetrahydrofuran / 1.17 h / 0 °C

3.1: zinc(II) triflate; sodium bicarbonate; EtSH / CH₂Cl₂ / 20 h

4.1: 496 mg / PPTS / CH₂Cl₂ / 14 h

With pyridinium p-toluenesulfonate; potassium hexamethylsilazane; zinc trifluoromethanesulfonate; sodium hydrogencarbonate; ozone; ethanethiol; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja027638q