acetic acid 2-{5-[5-(2-azetidin-1-yl-1,1-dimethylethoxy)pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-6-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)benzyl ester

Base Information

Chemical Name:acetic acid 2-{5-[5-(2-azetidin-1-yl-1,1-dimethylethoxy)pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-6-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)benzyl ester
CAS No.:1581692-38-7
Molecular Formula:C₃₈H₄₃N₇O₅
Molecular Weight:677.803
Hs Code.:

acetic acid 2-{5-[5-(2-azetidin-1-yl-1,1-dimethylethoxy)pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-6-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)benzyl ester

Synonyms:acetic acid 2-{5-[5-(2-azetidin-1-yl-1,1-dimethylethoxy)pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-6-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)benzyl ester

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Chemical Property of acetic acid 2-{5-[5-(2-azetidin-1-yl-1,1-dimethylethoxy)pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-6-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)benzyl ester

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Technology Process of acetic acid 2-{5-[5-(2-azetidin-1-yl-1,1-dimethylethoxy)pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-6-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)benzyl ester

There total 8 articles about acetic acid 2-{5-[5-(2-azetidin-1-yl-1,1-dimethylethoxy)pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-6-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360056-22-9
4-[5-(2-(azetidin-1-yl)-1,1-dimethylethoxy)pyridin-2-ylamino]-6-chloro-2-methyl-2H-pyridazin-3-one

: 1413063-68-9
acetic acid 2-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-6-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzyl ester

: 1581692-38-7
acetic acid 2-{5-[5-(2-azetidin-1-yl-1,1-dimethylethoxy)pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-6-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)benzyl ester

: 1581692-09-2
2-(3-{5-[5-(2-azetidin-1-yl-1,1-dimethylethoxy)pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-2-hydroxymethylphenyl)-6-tert-butyl-2H-phthalazin-1-one

Guidance literature:: With potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In water; butan-1-ol; at 110 ℃; for 2.5h; Overall yield = 112 mg; Inert atmosphere;

Reference yield:

: 1385022-20-7
6-tert-butyl-2H-phthalazin-1-one

: 1581692-38-7
acetic acid 2-{5-[5-(2-azetidin-1-yl-1,1-dimethylethoxy)pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-6-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)benzyl ester

: 1581692-09-2
2-(3-{5-[5-(2-azetidin-1-yl-1,1-dimethylethoxy)pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-2-hydroxymethylphenyl)-6-tert-butyl-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; tetraethylammonium chloride / N,N-dimethyl acetamide / 73 h / Inert atmosphere; Heating

2: sodium tetrahydroborate / dichloromethane; methanol / 0 - 20 °C / Inert atmosphere

3: triethylamine; dmap / dichloromethane / 20 °C

4: potassium acetate; palladium diacetate; XPhos / 2-methyltetrahydrofuran / 11 h / Inert atmosphere; Heating

5: XPhos; potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; water / 2.5 h / 110 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; potassium phosphate; tetraethylammonium chloride; potassium acetate; palladium diacetate; potassium carbonate; triethylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 2-methyltetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water; butan-1-ol;

Reference yield:

: 1581692-34-3
2-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-6-chlorobenzaldehyde

: 1581692-38-7
acetic acid 2-{5-[5-(2-azetidin-1-yl-1,1-dimethylethoxy)pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-6-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)benzyl ester

: 1581692-09-2
2-(3-{5-[5-(2-azetidin-1-yl-1,1-dimethylethoxy)pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-2-hydroxymethylphenyl)-6-tert-butyl-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / dichloromethane; methanol / 0 - 20 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 20 °C

3: potassium acetate; palladium diacetate; XPhos / 2-methyltetrahydrofuran / 11 h / Inert atmosphere; Heating

4: XPhos; potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; water / 2.5 h / 110 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; potassium phosphate; potassium acetate; palladium diacetate; triethylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 2-methyltetrahydrofuran; methanol; dichloromethane; water; butan-1-ol;