(Z)-ethyl 2-[2-(2,4-dichlorophenyl)hydrazono]-4-(4-chlorophenyl)-3-methyl-4-oxobutanoate

Base Information

• Chemical Name: (Z)-ethyl 2-[2-(2,4-dichlorophenyl)hydrazono]-4-(4-chlorophenyl)-3-methyl-4-oxobutanoate
• CAS No.: 434952-87-1
• Molecular Formula: C₁₉H₁₇Cl₃N₂O₃
• Molecular Weight: 427.715
• Mol file: 434952-87-1.mol

Synonyms:(Z)-ethyl 2-[2-(2,4-dichlorophenyl)hydrazono]-4-(4-chlorophenyl)-3-methyl-4-oxobutanoate

Chemical Property of (Z)-ethyl 2-[2-(2,4-dichlorophenyl)hydrazono]-4-(4-chlorophenyl)-3-methyl-4-oxobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-ethyl 2-[2-(2,4-dichlorophenyl)hydrazono]-4-(4-chlorophenyl)-3-methyl-4-oxobutanoate

There total 4 articles about (Z)-ethyl 2-[2-(2,4-dichlorophenyl)hydrazono]-4-(4-chlorophenyl)-3-methyl-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-(4-chlorophenyl)-3-methyl-4-oxydo-2-oxobuten-3-oate lithium salt (1012314-40-7) + 2,4-dichlorophenyl hydrazine hydrochloride (5446-18-4) → (Z)-ethyl 2-[2-(2,4-dichlorophenyl)hydrazono]-4-(4-chlorophenyl)-3-methyl-4-oxobutanoate (434952-87-1)

Guidance literature:

In ethanol; at 10 - 15 ℃; for 2h;

Reference yield:

4'-chloropropiophenone (6285-05-8) → (Z)-ethyl 2-[2-(2,4-dichlorophenyl)hydrazono]-4-(4-chlorophenyl)-3-methyl-4-oxobutanoate (434952-87-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / LDA; potassium t-butoxide / diethyl ether; tetrahydrofuran; heptane / 2.5 h / 20 °C

2: HCl / H₂O; CH₂Cl₂

3: ethanol / Heating

With hydrogenchloride; potassium tert-butylate; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; n-heptane; dichloromethane; water;

DOI:10.1002/jlcr.529

Reference yield:

(Z)-4-(4-chloro-phenyl)-2-hydroxy-3-methyl-4-oxo-but-2-enoic acid ethyl ester lithium salt → (Z)-ethyl 2-[2-(2,4-dichlorophenyl)hydrazono]-4-(4-chlorophenyl)-3-methyl-4-oxobutanoate (434952-87-1)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / H₂O; CH₂Cl₂

2: ethanol / Heating

With hydrogenchloride; In ethanol; dichloromethane; water;

DOI:10.1002/jlcr.529

upstream raw materials:

4-(4-chlorophenyl)-3-methyl-2,4-dioxobutyric acid ethyl ester

(2,4-dichlorophenyl)hydrazine

ethyl 4-(4-chlorophenyl)-3-methyl-4-oxydo-2-oxobuten-3-oate lithium salt

2,4-dichlorophenyl hydrazine hydrochloride

Downstream raw materials:

rimonabant acid

ethyl 1-(2,4-dichlorophenyl)-4-methyl-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate