C₂₀H₂₅N₂O₄PS

Base Information

• Chemical Name: C₂₀H₂₅N₂O₄PS
• CAS No.: 1001096-29-2
• Molecular Formula: C₂₀H₂₅N₂O₄PS
• Molecular Weight: 420.469
• Mol file: 1001096-29-2.mol

Synonyms:C₂₀H₂₅N₂O₄PS

Chemical Property of C₂₀H₂₅N₂O₄PS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₅N₂O₄PS

There total 4 articles about C₂₀H₂₅N₂O₄PS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-(chloromethyl)-2-methyl-1,3-thiazole (39238-07-8) + C15H20NO4P (1001095-46-0) → C20H25N2O4PS (1001096-29-2)

Guidance literature:

C₁₅H₂₀NO₄P; With chloro-trimethyl-silane; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

4-(chloromethyl)-2-methyl-1,3-thiazole; In dichloromethane; at 40 ℃; for 12.05h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.02.111

Reference yield:

diethyl (1S,2S)-1-amino-2-vinyl-cyclopropane-1-phosphonate (877068-76-3) → C20H25N2O4PS (1001096-29-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 17 h / 20 °C

2.1: pyridine; sodium iodide / 5 h / Reflux

3.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 2 h / 0 °C

4.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 2 h / -78 - 20 °C

4.2: Cooling with ice

5.1: chloro-trimethyl-silane; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

5.2: 12.05 h / 40 °C / Inert atmosphere

With pyridine; chloro-trimethyl-silane; oxalyl dichloride; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; lithium tri-t-butoxyaluminum hydride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium iodide; In tetrahydrofuran; dichloromethane; water; toluene;

DOI:10.1016/j.tetlet.2012.02.111

Reference yield:

C17H24NO5P (877068-78-5) → C20H25N2O4PS (1001096-29-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine; sodium iodide / 5 h / Reflux

2.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 2 h / 0 °C

3.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 2 h / -78 - 20 °C

3.2: Cooling with ice

4.1: chloro-trimethyl-silane; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.2: 12.05 h / 40 °C / Inert atmosphere

With pyridine; chloro-trimethyl-silane; oxalyl dichloride; tetra-(n-butyl)ammonium iodide; lithium tri-t-butoxyaluminum hydride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium iodide; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1016/j.tetlet.2012.02.111

upstream raw materials:

4-(chloromethyl)-2-methyl-1,3-thiazole

C₁₅H₂₀NO₄P

diethyl (1S,2S)-1-amino-2-vinyl-cyclopropane-1-phosphonate

C₁₇H₂₄NO₅P