39238-07-8

Usage

Uses

Used in Pharmaceutical Synthesis:
4-(CHLOROMETHYL)-2-METHYL-1,3-THIAZOLE is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical properties allow it to be incorporated into the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Production:
In the agrochemical industry, 4-(CHLOROMETHYL)-2-METHYL-1,3-THIAZOLE serves as an essential component in the production of various agrochemicals. Its reactivity and versatility make it suitable for the creation of effective and targeted agricultural products.
Used in Rubber Accelerator Manufacturing:
4-(CHLOROMETHYL)-2-METHYL-1,3-THIAZOLE is utilized as a crucial ingredient in the manufacturing of rubber accelerators. Its presence enhances the vulcanization process, leading to improved rubber properties and performance.
Used in Dye Production:
In the dye industry, 4-(CHLOROMETHYL)-2-METHYL-1,3-THIAZOLE is employed as a vital component in the production of various dyes. Its chemical structure contributes to the development of dyes with specific color characteristics and properties.
Used in Organic Compound Synthesis:
4-(CHLOROMETHYL)-2-METHYL-1,3-THIAZOLE is also used as an intermediate in the synthesis of a wide range of organic compounds. Its reactivity and compatibility with other chemical groups make it a valuable building block in organic chemistry.

InChI:InChI=1/C5H6ClNS.ClH/c1-4-7-5(2-6)3-8-4;/h3H,2H2,1H3;1H

Upstream product

• 64-17-5 ethanol 
• 62-55-5 thioacetamide 
• 534-07-6 1,3-Dichloroacetone 
• 105-56-6 ethyl 2-cyanoacetate 
• 76632-23-0 4-(hydroxymethyl)-2-methylthiazole 
• 21262-97-5 4-chloromethyl-2-methyl-4,5-dihydro-thiazol-4-ol 
• 7803-96-5 2-Chloro-2-(chloromethyl)oxirane 
• 77470-53-2 4-chloromethyl-2-methylthiazole hydrochloride 
• 802868-31-1 1-((1-aminoethyl)thio)-3-chloropropan-2-one 
• 22043-38-5 C₅H₈ClNOS*ClH 
• 6436-59-5 ethyl 2-methylthiazole-4-carboxylate 

Downstream Products

• 91615-65-5 (2-methylthiazol-4-yl)methanethiol 
• 100710-55-2 4-(2-methyl-thiazol-4-yl)-3-phenyl-butan-2-one 
• 39232-49-0 7-(2-methyl-thiazol-4-ylmethoxy)-4-oxo-3-phenyl-4H-chromene-2-carboxylic acid ethyl ester 
• 103787-88-8 5-[4-(2-Methyl-thiazol-4-ylmethoxy)-benzyl]-thiazolidine-2,4-dione 
• 149168-09-2 methyl 3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(2-methylthiazol-4-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoate 
• 848316-21-2 4-(2-methyl-thiazol-4-ylmethoxy)-benzaldehyde 
• 184246-51-3 2-methyl-4-thiazolylmethyl diphenylphosphine oxide 
• 594815-24-4 3-(4-chloro-phenyl)-4-(2-methyl-thiazol-4-ylmethyl)-2-phenyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester 
• 313682-07-4 N-(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-oxycarbonyl-(4S,5R)-4-[4-(2-methylthiazolo-4-methyloxy)-benzyl]-5-i-butyl-[(3,4-methylenedioxyphenyl)sulfonyl]-aminomethyl-2,2-dimethyl-oxazolidine 
• 13458-33-8 (2-methyl-4-thiazolyl)acetonitrile 
• 20949-84-2 2-methylthiazole-4-carbaldehyde 
• 152044-54-7 epothilone B 

Relevant academic research and scientific papers

COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors together with a second compound useful in the treatment of a neurodegenerative disorder and their combined use as a medicament, in particular for the treatment of neurodegenerative and/or cognitive disorders.

MACROCYCLES AS PDE1 INHIBITORS

The present invention provides macrocycles of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS

The present invention provides 1H-pyrazolo[4,3-b]pyridines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors together with a second compound which compound is useful in the treatment of a psychiatric disorder and their combined use as a medicament, in particular for the treatment of psychiatric and/or cognitive disorders.

1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

The Total Synthesis of Epothilone D as a Yardstick for Probing New Methodologies

Here, a concise and highly convergent synthesis of epothilone D was investigated, relying on fragments of equal complexity that could be prepared in gram scale quantities. The strategy to construct the fragments includes the use of a previously reported enantiospecific zinc-catalyzed cross-coupling of an α-hydroxy ester triflate with a Grignard reagent, the application of a hydroboration/boron–magnesium exchange sequence for the rapid construction of the Z-substituted trisubstituted double bond present in the natural product, and a Noyori-type hydrogenation to install the β-hydroxy ester moiety of the southern part. The key to success is the diastereoselective head-to-tail macrolactonization by an intramolecular addition of the corresponding ω-alkynyl-substituted carboxylic acids to construct a new stereocenter in the macrocyclic core structure in one single step.

QUINAZOLINE DERIVATIVE

Provided are a quinazoline derivative, a pharmaceutical composition containing the same, a method for preparation of said derivative, and an application of same as an anti-cancer drug.

NOVEL COMPOUND, ORGANIC CATION TRANSPORTER 3 DETECTION AGENT, AND ORGANIC CATION TRANSPORTER 3 ACTIVITY INHIBITOR

[Problem] The present invention addresses the problem of providing a novel compound. The present invention also addresses the problem of providing an OCT3 detection agent or an OCT3 activity inhibitor, which comprises the novel compound. [Solution] A compound represented by formula (A), a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof. ????????R1-R2-R3-R4?????(A)

SYNTHETIC PRECURSOR OF EPOTHILONE FOR IMPROVING PRODUCTION OF EPOTHILONE AND METHOD FOR PREPARING EPOTHILONE USING THE SAME

The present invention relates to a compound for increasing production of epothilone in actinomyces, and to a method for producing epothilone with increased yield. The method for producing epothilone of the present invention includes a step of culturing actinomyces in which epothilone-biosynthesizing genes in Sorangium cellulosum including epoD, epoE, epoF, orf6, orf3, and orf14 are introduced in a culture medium. According to the present invention, it is possible to increase the production yield of epothilone in actinomyces, even in actinomyces in which epoA, epoP, epoB, and epoC are not introduced therein.COPYRIGHT KIPO 2016

Structure-activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers. Part II: P2/P3 region and discovery of cobicistat (GS-9350)

The HIV protease inhibitor (PI) ritonavir (RTV) has been widely used as a pharmacoenhancer for other PIs, which are substrates of cytochrome P450 3A (CYP3A). However the potent anti-HIV activity of ritonavir may limit its use as a pharmacoenhancer with other classes of anti-HIV agents. Ritonavir is also associated with limitations such as poor physicochemical properties. To address these issues a series of compounds with replacements at the P2 and/or P3 region was designed and evaluated as novel CYP3A inhibitors. Through these efforts, a potent and selective inhibitor of CYP3A, GS-9350 (cobicistat) with improved physiochemical properties was discovered.