Technology Process of ethyl 2-(4-bromobenzyl)-2,3-butadienoate
There total 8 articles about ethyl 2-(4-bromobenzyl)-2,3-butadienoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C29H27PO2Br(1+)*Br(1-);
With
triethylamine;
In
dichloromethane;
for 0.5h;
acetyl chloride;
In
dichloromethane;
at 20 ℃;
for 16h;
Further stages.;
DOI:10.1021/ja070274n
- Guidance literature:
-
1-bromomethyl-4-bromobenzene; ethyl (triphenylphosphoranylidene)acetate;
In
chloroform;
for 72h;
Inert atmosphere;
Schlenk technique;
Reflux;
With
triethylamine;
In
chloroform;
at 20 ℃;
for 0.5h;
Inert atmosphere;
Schlenk technique;
Reflux;
acetyl chloride;
In
chloroform;
at 20 ℃;
for 24h;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/chem.201805823
- Guidance literature:
-
ethyl (triphenylphosphoranylidene)acetate; 4-bromobenzyl halide;
In
chloroform;
Reflux;
Inert atmosphere;
With
triethylamine;
In
dichloromethane;
for 1h;
Inert atmosphere;
With
acetyl chloride;
In
dichloromethane;
at 20 ℃;
Inert atmosphere;
DOI:10.1021/acs.orglett.6b02885
