(S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(pyrrolidin-3-yloxy)phenyl)quinazolin-2-amine

Base Information

Chemical Name:(S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(pyrrolidin-3-yloxy)phenyl)quinazolin-2-amine
CAS No.:1202033-90-6
Molecular Formula:C₂₂H₂₁BrN₆O
Molecular Weight:465.352
Hs Code.:

Synonyms:(S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(pyrrolidin-3-yloxy)phenyl)quinazolin-2-amine

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Chemical Property of (S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(pyrrolidin-3-yloxy)phenyl)quinazolin-2-amine

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Technology Process of (S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(pyrrolidin-3-yloxy)phenyl)quinazolin-2-amine

There total 6 articles about (S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(pyrrolidin-3-yloxy)phenyl)quinazolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202036-17-6
C₂₇H₂₉BrN₆O₃

: 1202033-90-6
(S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(pyrrolidin-3-yloxy)phenyl)quinazolin-2-amine

Guidance literature:: C₂₇H₂₉BrN₆O₃; With trifluoroacetic acid; In dichloromethane; for 0.25h;

With water; sodium carbonate; sodium hydroxide; In ethanol; dichloromethane; pH=~ 11;

Reference yield:

: 16618-67-0
3-bromo-5-nitroanisole

: 1202033-90-6
(S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(pyrrolidin-3-yloxy)phenyl)quinazolin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron tribromide / dichloromethane / 20 °C / Cooling with ice bath

1.2: -78 - 20 °C

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1.5 h / 80 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.33 h / 20 °C

3.2: 15 h

4.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C / 760.05 Torr / Inert atmosphere of argon

5.1: isopropyl alcohol / 16 h / 100 °C

6.1: trifluoroacetic acid / dichloromethane / 0.25 h

6.2: pH ~ 11

With hydrogen; boron tribromide; sodium carbonate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol; 2.1: Suzuki Coupling / 3.1: Mitsunobu reaction / 3.2: Mitsunobu reaction;

Reference yield:

: 1202036-15-4
C₁₉H₂₄N₄O₅

: 1202033-90-6
(S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(pyrrolidin-3-yloxy)phenyl)quinazolin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C / 760.05 Torr / Inert atmosphere of argon

2.1: isopropyl alcohol / 16 h / 100 °C

3.1: trifluoroacetic acid / dichloromethane / 0.25 h

3.2: pH ~ 11

With hydrogen; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; isopropyl alcohol;