(R)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (1R,2S)-2-benzhydryloxycarbonyl-2-benzyloxycarbonylamino-1-methyl-ethyl ester

Base Information

Chemical Name:(R)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (1R,2S)-2-benzhydryloxycarbonyl-2-benzyloxycarbonylamino-1-methyl-ethyl ester
CAS No.:128849-59-2
Molecular Formula:C₃₅H₄₁NO₈
Molecular Weight:603.712
Hs Code.:

Synonyms:(R)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (1R,2S)-2-benzhydryloxycarbonyl-2-benzyloxycarbonylamino-1-methyl-ethyl ester

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Chemical Property of (R)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (1R,2S)-2-benzhydryloxycarbonyl-2-benzyloxycarbonylamino-1-methyl-ethyl ester

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Technology Process of (R)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (1R,2S)-2-benzhydryloxycarbonyl-2-benzyloxycarbonylamino-1-methyl-ethyl ester

There total 7 articles about (R)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (1R,2S)-2-benzhydryloxycarbonyl-2-benzyloxycarbonylamino-1-methyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 98694-87-2
N-benzyloxycarbonyl-L-threonine benzhydryl ester

: 128829-04-9
(R)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid

: 128849-59-2
(R)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (1R,2S)-2-benzhydryloxycarbonyl-2-benzyloxycarbonylamino-1-methyl-ethyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In ethyl acetate; for 2h; Ambient temperature;
DOI:10.1016/S0040-4039(00)70713-1

Reference yield:

: (S)-1-Benzyloxy-3-ethyl-pentane-2,3-diol

: 128849-59-2
(R)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (1R,2S)-2-benzhydryloxycarbonyl-2-benzyloxycarbonylamino-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: DMP, H₂SO₄ / 2 h / Ambient temperature

2: H₂ / Pd(OH)2 / methanol / 1 h / Ambient temperature

3: NaIO₄, RuCl₃ / CCl₄; acetonitrile; H₂O / 1 h / Ambient temperature

4: 83 percent / DCC,DMAP / ethyl acetate / 2 h / Ambient temperature

With dmap; ruthenium trichloride; sodium periodate; phthalic acid dimethyl ester; sulfuric acid; hydrogen; dicyclohexyl-carbodiimide; palladium dihydroxide; In methanol; tetrachloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1016/S0040-4039(00)70713-1

Reference yield:

: (S)-1-Benzyloxy-2-methoxymethoxy-pentan-3-ol

: 128849-59-2
(R)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (1R,2S)-2-benzhydryloxycarbonyl-2-benzyloxycarbonylamino-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: PCC,MS₃AP / CH₂Cl₂ / 0.5 h / Ambient temperature

2: diethyl ether / 1.5 h / Ambient temperature

3: aq. HCl / dioxane / 3 h / 50 °C

4: DMP, H₂SO₄ / 2 h / Ambient temperature

5: H₂ / Pd(OH)2 / methanol / 1 h / Ambient temperature

6: NaIO₄, RuCl₃ / CCl₄; acetonitrile; H₂O / 1 h / Ambient temperature

7: 83 percent / DCC,DMAP / ethyl acetate / 2 h / Ambient temperature

With hydrogenchloride; dmap; ruthenium trichloride; sodium periodate; phthalic acid dimethyl ester; PCC,MS₃AP; sulfuric acid; hydrogen; dicyclohexyl-carbodiimide; palladium dihydroxide; In 1,4-dioxane; methanol; tetrachloromethane; diethyl ether; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1016/S0040-4039(00)70713-1