{(5R,6S,9S,10S,11R)-10-Hydroxy-5,11-dimethyl-2-[1-methyl-prop-(Z)-ylidene]-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-carbamic acid benzyl ester

Base Information

Chemical Name:{(5R,6S,9S,10S,11R)-10-Hydroxy-5,11-dimethyl-2-[1-methyl-prop-(Z)-ylidene]-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-carbamic acid benzyl ester
CAS No.:128829-09-4
Molecular Formula:C₂₉H₃₅N₃O₈
Molecular Weight:553.612
Hs Code.:

{(5R,6S,9S,10S,11R)-10-Hydroxy-5,11-dimethyl-2-[1-methyl-prop-(Z)-ylidene]-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-carbamic acid benzyl ester

Synonyms:{(5R,6S,9S,10S,11R)-10-Hydroxy-5,11-dimethyl-2-[1-methyl-prop-(Z)-ylidene]-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-carbamic acid benzyl ester

Suppliers and Price of {(5R,6S,9S,10S,11R)-10-Hydroxy-5,11-dimethyl-2-[1-methyl-prop-(Z)-ylidene]-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-carbamic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {(5R,6S,9S,10S,11R)-10-Hydroxy-5,11-dimethyl-2-[1-methyl-prop-(Z)-ylidene]-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of {(5R,6S,9S,10S,11R)-10-Hydroxy-5,11-dimethyl-2-[1-methyl-prop-(Z)-ylidene]-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-carbamic acid benzyl ester

There total 15 articles about {(5R,6S,9S,10S,11R)-10-Hydroxy-5,11-dimethyl-2-[1-methyl-prop-(Z)-ylidene]-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: {(5R,6S,9S,10S,11R)-2-[1-(Diethoxy-phosphoryloxy)-prop-(E)-ylidene]-10-hydroxy-5,11-dimethyl-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-carbamic acid benzyl ester

: 128829-09-4
{(5R,6S,9S,10S,11R)-10-Hydroxy-5,11-dimethyl-2-[1-methyl-prop-(Z)-ylidene]-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-carbamic acid benzyl ester

Guidance literature:: In tetrahydrofuran; at -70 - -30 ℃; for 3h;
DOI:10.1016/S0040-4039(00)70713-1

Reference yield:

: ((S)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methanol

: 128829-09-4
{(5R,6S,9S,10S,11R)-10-Hydroxy-5,11-dimethyl-2-[1-methyl-prop-(Z)-ylidene]-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: NaIO₄, RuCl₃ / CCl₄; acetonitrile; H₂O / 1 h / Ambient temperature

2: 83 percent / DCC,DMAP / ethyl acetate / 2 h / Ambient temperature

3: aq. TFA / 1 h / Ambient temperature

4: ethyl acetate; petroleum ether / 2.5 h / Ambient temperature

5: DCC, DMAP / ethyl acetate / 2.5 h / Ambient temperature

6: 1.) aq. HCl 2.) aq. TFA / 1 ) dioxane, 35 deg C, 12 h 2 ) rt., 20 min.

7: H₂ / Raney-Ni W-4 / methanol / 0.67 h / 35 °C

8: DCC, HOBt / dimethylformamide / 68 h / 2 °C

9: 95 percent / SOCl₂ / pyridine / 1 h / -30 °C

10: 84 percent / O₃/O₂ / CH₂Cl₂ / 0 h / -78 °C

11: 1)NaH / 1)THF, 0 deg C, 15 min., 2)0 deg C, 1 h

12: 25 percent / tetrahydrofuran / 3 h / -70 - -30 °C

With hydrogenchloride; dmap; ruthenium trichloride; sodium periodate; thionyl chloride; hydrogen; oxygen; sodium hydride; benzotriazol-1-ol; ozone; dicyclohexyl-carbodiimide; trifluoroacetic acid; Raney-Ni W-4; In tetrahydrofuran; pyridine; methanol; tetrachloromethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; Petroleum ether;
DOI:10.1016/S0040-4039(00)70713-1

Reference yield:

: 128829-04-9
(R)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid

: 128829-09-4
{(5R,6S,9S,10S,11R)-10-Hydroxy-5,11-dimethyl-2-[1-methyl-prop-(Z)-ylidene]-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 83 percent / DCC,DMAP / ethyl acetate / 2 h / Ambient temperature

2: aq. TFA / 1 h / Ambient temperature

3: ethyl acetate; petroleum ether / 2.5 h / Ambient temperature

4: DCC, DMAP / ethyl acetate / 2.5 h / Ambient temperature

5: 1.) aq. HCl 2.) aq. TFA / 1 ) dioxane, 35 deg C, 12 h 2 ) rt., 20 min.

6: H₂ / Raney-Ni W-4 / methanol / 0.67 h / 35 °C

7: DCC, HOBt / dimethylformamide / 68 h / 2 °C

8: 95 percent / SOCl₂ / pyridine / 1 h / -30 °C

9: 84 percent / O₃/O₂ / CH₂Cl₂ / 0 h / -78 °C

10: 1)NaH / 1)THF, 0 deg C, 15 min., 2)0 deg C, 1 h

11: 25 percent / tetrahydrofuran / 3 h / -70 - -30 °C

With hydrogenchloride; dmap; thionyl chloride; hydrogen; oxygen; sodium hydride; benzotriazol-1-ol; ozone; dicyclohexyl-carbodiimide; trifluoroacetic acid; Raney-Ni W-4; In tetrahydrofuran; pyridine; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; Petroleum ether;
DOI:10.1016/S0040-4039(00)70713-1