1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-ol

Base Information

• Chemical Name: 1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-ol
• CAS No.: 263720-76-9
• Molecular Formula: C₁₈H₂₈OSi
• Molecular Weight: 288.505
• Mol file: 263720-76-9.mol

Synonyms:1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-ol

Chemical Property of 1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-ol

There total 10 articles about 1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(tri(isopropyl)silyl)-1-phenylprop-2-yn-1-one (503595-76-4) → 1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-ol (263720-76-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.5h;

DOI:10.1039/c1ob06010d

Reference yield: 99.0%

tris-iso-propylsilyl acetylene (89343-06-6) + benzaldehyde (100-52-7) → 1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-ol (263720-76-9)

Guidance literature:

tris-iso-propylsilyl acetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

benzaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; hexane; Inert atmosphere;

DOI:10.1002/chem.201002769

Reference yield:

triisopropylsilyl chloride (13154-24-0) + 1-Phenyl-2-propyn-1-ol (4187-87-5) → 1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-ol (263720-76-9)

Guidance literature:

1-Phenyl-2-propyn-1-ol; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h; Inert atmosphere;

triisopropylsilyl chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.08.114

upstream raw materials:

tris-iso-propylsilyl acetylene

benzaldehyde

phenyllithium

N,N-dimethyl-formamide

Downstream raw materials:

1-(triisopropylsilyl)-3-(triisopropylsilyloxy)-3-phenylprop-1-yne

benzyl (1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-yl)carbamate

triisopropyl(3-phenylprop-1-yn-1-yl)silane

1-phenyl-3-triisopropylsilanylpropen-1-one