benzyl (2R)-2-Benzyl-3-morpholinocarbonylpropionate

Base Information

• Chemical Name: benzyl (2R)-2-Benzyl-3-morpholinocarbonylpropionate
• CAS No.: 116129-89-6
• Molecular Formula: C₂₂H₂₅NO₄
• Molecular Weight: 367.445
• Mol file: 116129-89-6.mol

Synonyms:benzyl (2R)-2-Benzyl-3-morpholinocarbonylpropionate

Chemical Property of benzyl (2R)-2-Benzyl-3-morpholinocarbonylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (2R)-2-Benzyl-3-morpholinocarbonylpropionate

There total 6 articles about benzyl (2R)-2-Benzyl-3-morpholinocarbonylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

morpholine (110-91-8,99108-56-2) + (3R)-3-Benzyloxycarbonyl-3-phenylmethylpropionic acid (116129-80-7) → benzyl (2R)-2-Benzyl-3-morpholinocarbonylpropionate (116129-89-6)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; Multistep reaction; 1.) CH₂Cl₂, 0-20 deg C, 30 min, 2.) CH₂Cl₂, RT, overnight;

DOI:10.1021/jm00088a005

Reference yield:

benzyl (2R)-2-<(tert-butyloxycarbonyl)methyl>-3-phenylpropionate (116129-88-5) → benzyl (2R)-2-Benzyl-3-morpholinocarbonylpropionate (116129-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, 5 min, 2.) 1 h

With 4-methyl-morpholine; trifluoroacetic acid; isobutyl chloroformate; In dichloromethane;

DOI:10.1021/jm00120a006

Reference yield:

(4S)-3-(3-phenylpropionyl)-4-(2-propyl)oxazolidin-2-one (95798-31-5) → benzyl (2R)-2-Benzyl-3-morpholinocarbonylpropionate (116129-89-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) sodium hexamethyldisilylamide / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 1 h

2: 94 percent / n-butyllithium / tetrahydrofuran / 1 h / 0 °C

3: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / Ambient temperature

4: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, 5 min, 2.) 1 h

With 4-methyl-morpholine; n-butyllithium; sodium hexamethyldisilazane; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00120a006

upstream raw materials:

morpholine

(3R)-3-Benzyloxycarbonyl-3-phenylmethylpropionic acid

(4S)-3-(3-phenylpropionyl)-4-(2-propyl)oxazolidin-2-one

benzyl (2R)-2-<(tert-butyloxycarbonyl)methyl>-3-phenylpropionate

Downstream raw materials:

(R)-2-Benzyl-N-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

(2S,3R,4S)-2-<-3-(4-thiazolyl)-L-alanyl>amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

2(R)-2-<(4-morpholinylcarbonyl)methyl>-3-phenylpropionic acid