6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1)

Base Information

• Chemical Name: 6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1)
• CAS No.: 1289646-93-0
• Molecular Formula: C₁₀H₉Cl₂NO₂*ClH
• Molecular Weight: 282.554

Synonyms:5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid hydrochloride

Chemical Property of 6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5,7-Dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylicacidhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

• Uses: 6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1)?is a quinoline derivative used in pharmaceutical synthesis.

Technology Process of 6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1)

There total 20 articles about 6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid (1194550-56-5) → 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid hydrochloride (1289646-93-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

Reference yield: 91.3%

2-benzyl-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid → 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid hydrochloride (1289646-93-0)

Guidance literature:

With hydrogenchloride; 5%-palladium/activated carbon; hydrogen; In methanol; water; at 60 ℃; for 20h; under 1520.1 Torr; Temperature; Pressure; Solvent; Autoclave;

Reference yield: 88.5%

C21H16Cl4N2O4(2-)*2Li(1+) → 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid hydrochloride (1289646-93-0)

Guidance literature:

With hydrogenchloride; n-butyllithium; for 5h; Reagent/catalyst;

DOI:10.1021/acs.oprd.1c00229

upstream raw materials:

(3,5-dichloro-benzylidene)-(2,2-diethoxy-ethyl)-amine

5,7-dichloro isoquinoline

5,7-dichloro-1,2,3,4-tetrahydroisoquinoline

3,5-dichlorobenzaldehyde

Downstream raw materials:

2-(tert-butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

benzyl (S)-2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-[3-(methylsulfonyl)phenyl]propanoate hydrochloride

((S)-benzyl 2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-methylsulfonyl)phenyl)propanoate

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

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