5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

Base Information

Chemical Name:5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid
CAS No.:1194550-56-5
Molecular Formula:C₂₉H₂₃Cl₂NO₂
Molecular Weight:488.413
Hs Code.:
Mol file:1194550-56-5.mol

Synonyms:5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

Suppliers and Price of 5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5,7-Dichloro-1,2,3,4-tetrahydro-2-(triphenylmethyl)-6-isoquinolinecarboxylicAcid
500mg
$ 2750.00

Total 15 raw suppliers

Chemical Property of 5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

Chemical Property:

Boiling Point:598.2±50.0 °C(Predicted)
PKA:1.40±0.20(Predicted)
Density:1.323±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

5,7-Dichloro-1,2,3,4-tetrahydro-2-(triphenylmethyl)-6-isoquinolinecarboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 5,7-Dichloro-1,2,3,4-tetrahydro-2-(triphenylmethyl)-6-isoquinolinecarboxylic Acid, can be sued in the preparation of novel series of compounds which has been found to be a potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for treating dry eye.

Technology Process of 5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

There total 8 articles about 5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 124-38-9,18923-20-1
carbon dioxide

: 1289646-72-5
C₂₈H₂₃Cl₂N

: 1194550-56-5
5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

Guidance literature:: With n-butyllithium; N,N,N,N,-tetramethylethylenediamine;

Reference yield: 75.0%

: 201230-82-2
carbon monoxide

: 1289646-72-5
C₂₈H₂₃Cl₂N

: 1194550-56-5
5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

Guidance literature:: C₂₈H₂₃Cl₂N; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -78 - 20 ℃;

carbon monoxide; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/ml2002482

Reference yield:

: 10203-08-4
3,5-dichlorobenzaldehyde

: 1194550-56-5
5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; sodium cyanoborohydride / 20 °C

2.1: aluminum (III) chloride / 185 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

4.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / -78 - 20 °C

4.2: -78 - 20 °C

With methanol; aluminum (III) chloride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ml2002482