7,8-dimethoxy-(3-methyl-1-(4-piperazin-1-yl)phenyl)-3H-pyrazolo[3,4-c]quinoline

Base Information

Chemical Name:7,8-dimethoxy-(3-methyl-1-(4-piperazin-1-yl)phenyl)-3H-pyrazolo[3,4-c]quinoline
CAS No.:1353636-01-7
Molecular Formula:C₂₃H₂₅N₅O₂
Molecular Weight:403.484
Hs Code.:

Synonyms:7,8-dimethoxy-(3-methyl-1-(4-piperazin-1-yl)phenyl)-3H-pyrazolo[3,4-c]quinoline

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Chemical Property of 7,8-dimethoxy-(3-methyl-1-(4-piperazin-1-yl)phenyl)-3H-pyrazolo[3,4-c]quinoline

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Technology Process of 7,8-dimethoxy-(3-methyl-1-(4-piperazin-1-yl)phenyl)-3H-pyrazolo[3,4-c]quinoline

There total 6 articles about 7,8-dimethoxy-(3-methyl-1-(4-piperazin-1-yl)phenyl)-3H-pyrazolo[3,4-c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 470478-90-1
tert-butyl 4-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate

: 1353635-02-5
1-bromo-7,8-dimethoxy-3-methyl-3H-pyrazolo[3,4-c]quinoline

: 1353636-01-7
7,8-dimethoxy-(3-methyl-1-(4-piperazin-1-yl)phenyl)-3H-pyrazolo[3,4-c]quinoline

Guidance literature:: tert-butyl 4-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate; 1-bromo-7,8-dimethoxy-3-methyl-3H-pyrazolo[3,4-c]quinoline; With trans-bis(tricyclohexylphosphine)palladium(II) dichloride; potassium hydroxide; In 1,4-dioxane; water; at 110 ℃; for 1.5h; Inert atmosphere; Microwave irradiation;

With formic acid; at 20 ℃; for 18h;

Reference yield:

: 70945-28-7
3-amino-6,7-dimethoxy-4-methylquinoline

: 1353636-01-7
7,8-dimethoxy-(3-methyl-1-(4-piperazin-1-yl)phenyl)-3H-pyrazolo[3,4-c]quinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; sodium nitrite / water; mineral oil / 3 h / 20 °C

2.1: bromine / water / 1 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: potassium hydroxide; trans-bis(tricyclohexylphosphine)palladium(II) dichloride / water; 1,4-dioxane / 1.5 h / 110 °C / Inert atmosphere; Microwave irradiation

4.2: 18 h / 20 °C

With trans-bis(tricyclohexylphosphine)palladium(II) dichloride; bromine; potassium carbonate; acetic acid; potassium hydroxide; sodium nitrite; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1353635-95-6
7,8-dimethoxy-3H-pyrazolo[3,4-c]-quinoline

: 1353636-01-7
7,8-dimethoxy-(3-methyl-1-(4-piperazin-1-yl)phenyl)-3H-pyrazolo[3,4-c]quinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine / water / 1 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

3.1: potassium hydroxide; trans-bis(tricyclohexylphosphine)palladium(II) dichloride / water; 1,4-dioxane / 1.5 h / 110 °C / Inert atmosphere; Microwave irradiation

3.2: 18 h / 20 °C

With trans-bis(tricyclohexylphosphine)palladium(II) dichloride; bromine; potassium carbonate; potassium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;