6,7-dimethoxy-4-methyl-3-nitroquinoline

Base Information

Chemical Name:6,7-dimethoxy-4-methyl-3-nitroquinoline
CAS No.:70945-27-6
Molecular Formula:C₁₂H₁₂N₂O₄
Molecular Weight:248.238
Hs Code.:

Synonyms:6,7-dimethoxy-4-methyl-3-nitroquinoline

Suppliers and Price of 6,7-dimethoxy-4-methyl-3-nitroquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6,7-dimethoxy-4-methyl-3-nitroquinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6,7-dimethoxy-4-methyl-3-nitroquinoline

There total 1 articles about 6,7-dimethoxy-4-methyl-3-nitroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4101-30-8
2-amino-4,5-dimethoxyacetophenone

: 70945-27-6
6,7-dimethoxy-4-methyl-3-nitroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: aqueous HCl

2: acetone; activated aluminium oxide

With hydrogenchloride; aluminum oxide; acetone;
DOI:10.1039/jr9500000395

Reference yield:

: 70945-27-6
6,7-dimethoxy-4-methyl-3-nitroquinoline

: 1353635-72-9
1-[4-(4-ethylpiperazin-1-yl)phenyl]-7,8-dimethoxy-3-methyl-3H-pyrazolo[3,4-c]quinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran / 16 h / 20 °C

2.1: acetic acid; sodium nitrite / water; mineral oil / 3 h / 20 °C

3.1: bromine / water / 1 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

5.1: potassium hydroxide; trans-bis(tricyclohexylphosphine)palladium(II) dichloride / water; 1,4-dioxane / 1.5 h / 110 °C / Inert atmosphere; Microwave irradiation

5.2: 18 h / 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With trans-bis(tricyclohexylphosphine)palladium(II) dichloride; 5%-palladium/activated carbon; hydrogen; bromine; potassium carbonate; acetic acid; potassium hydroxide; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 70945-27-6
6,7-dimethoxy-4-methyl-3-nitroquinoline

: 1353636-01-7
7,8-dimethoxy-(3-methyl-1-(4-piperazin-1-yl)phenyl)-3H-pyrazolo[3,4-c]quinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran / 16 h / 20 °C

2.1: acetic acid; sodium nitrite / water; mineral oil / 3 h / 20 °C

3.1: bromine / water / 1 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

5.1: potassium hydroxide; trans-bis(tricyclohexylphosphine)palladium(II) dichloride / water; 1,4-dioxane / 1.5 h / 110 °C / Inert atmosphere; Microwave irradiation

5.2: 18 h / 20 °C

With trans-bis(tricyclohexylphosphine)palladium(II) dichloride; 5%-palladium/activated carbon; hydrogen; bromine; potassium carbonate; acetic acid; potassium hydroxide; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;