(2R,3R,4S,5R)-3-Hydroxy-2-hydroxymethyl-4-(4-methoxy-benzyloxy)-5-(4-methoxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(2R,3R,4S,5R)-3-Hydroxy-2-hydroxymethyl-4-(4-methoxy-benzyloxy)-5-(4-methoxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:757244-61-4
Molecular Formula:C₂₆H₃₅NO₈
Molecular Weight:489.566
Hs Code.:

Synonyms:(2R,3R,4S,5R)-3-Hydroxy-2-hydroxymethyl-4-(4-methoxy-benzyloxy)-5-(4-methoxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (2R,3R,4S,5R)-3-Hydroxy-2-hydroxymethyl-4-(4-methoxy-benzyloxy)-5-(4-methoxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (2R,3R,4S,5R)-3-Hydroxy-2-hydroxymethyl-4-(4-methoxy-benzyloxy)-5-(4-methoxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 8 articles about (2R,3R,4S,5R)-3-Hydroxy-2-hydroxymethyl-4-(4-methoxy-benzyloxy)-5-(4-methoxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 757244-53-4
[(1R,2S,3R)-3-Hydroxy-2-(4-methoxy-benzyloxy)-1-(4-methoxy-phenoxymethyl)-pent-4-enyl]-carbamic acid tert-butyl ester

: 757244-61-4
(2R,3R,4S,5R)-3-Hydroxy-2-hydroxymethyl-4-(4-methoxy-benzyloxy)-5-(4-methoxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 757244-58-9
[(1R,2S,3S)-3-Hydroxy-2-(4-methoxy-benzyloxy)-1-(4-methoxy-phenoxymethyl)-3-(R)-oxiranyl-propyl]-carbamic acid tert-butyl ester

Guidance literature:: With tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium; In decane; toluene; at 20 ℃; for 16h;
DOI:10.1016/j.tetlet.2004.06.048

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 757244-61-4
(2R,3R,4S,5R)-3-Hydroxy-2-hydroxymethyl-4-(4-methoxy-benzyloxy)-5-(4-methoxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / NaH / dimethylformamide / 10 h / 0 °C

2: DMAP / tetrahydrofuran / 4 h / Heating

3: H₂NNH₂ / methanol / 4 h

4: 90 percent / DIBAL / CH₂Cl₂ / 3 h / -78 °C

5: tetrahydrofuran / 2 h / -50 - 20 °C

6: 42 percent / VO(acac)2; t-BuOOH / toluene; decane / 16 h / 20 °C

With tert.-butylhydroperoxide; dmap; bis(acetylacetonate)oxovanadium; sodium hydride; diisobutylaluminium hydride; hydrazine; In tetrahydrofuran; methanol; decane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2004.06.048

Reference yield:

: 544455-39-2
(2S,3R)-3-Acetylamino-2-hydroxy-4-(4-methoxy-phenoxy)-butyric acid ethyl ester

: 757244-61-4
(2R,3R,4S,5R)-3-Hydroxy-2-hydroxymethyl-4-(4-methoxy-benzyloxy)-5-(4-methoxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / NaH / dimethylformamide / 10 h / 0 °C

2: DMAP / tetrahydrofuran / 4 h / Heating

3: H₂NNH₂ / methanol / 4 h

4: 90 percent / DIBAL / CH₂Cl₂ / 3 h / -78 °C

5: tetrahydrofuran / 2 h / -50 - 20 °C

6: 42 percent / VO(acac)2; t-BuOOH / toluene; decane / 16 h / 20 °C

With tert.-butylhydroperoxide; dmap; bis(acetylacetonate)oxovanadium; sodium hydride; diisobutylaluminium hydride; hydrazine; In tetrahydrofuran; methanol; decane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2004.06.048