Clonazepam

Base Information Edit

Chemical Name:Clonazepam
CAS No.:1622-61-3
Deprecated CAS:106955-87-7
Molecular Formula:C₁₅H₁₀ClN₃O₃
Molecular Weight:315.716
Hs Code.:2933910000
European Community (EC) Number:216-596-2
NSC Number:179913
UNII:5PE9FDE8GB
DSSTox Substance ID:DTXSID1022845
Nikkaji Number:J5.233G
Wikipedia:Clonazepam
Wikidata:Q407988
NCI Thesaurus Code:C28935
RXCUI:2598
Pharos Ligand ID:P1YWX34JTACH
Metabolomics Workbench ID:43305
ChEMBL ID:CHEMBL452
Mol file:1622-61-3.mol

Synonyms:2H-1,4-Benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-7-nitro-;Antelepsin;Clonazepam;Klonopin;Rivotril;Ro 5-4023;Ro 54023

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Clonazepam Edit

Chemical Property:

Appearance/Colour:tan solid
Vapor Pressure:4.27E-11mmHg at 25°C
Melting Point:236.5-238.5 °C
Refractive Index:1.701
Boiling Point:524.5 °C at 760 mmHg
PKA:1.5, 10.5(at 25℃)
Flash Point:271 °C
PSA：87.28000
Density:1.5 g/cm³
LogP:3.13450
Storage Temp.:2-8°C
Solubility.:Practically insoluble in water, slightly soluble in alcohol and in methanol.
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:315.0410689
Heavy Atom Count:22
Complexity:491

Purity/Quality:

Safty Information:

Pictogram(s): F, T
Hazard Codes:F,T
Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45-24/25-22

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Anticonvulsants
Canonical SMILES:C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3Cl
Recent ClinicalTrials:Burning Mouth Syndrome - New Diagnostic Criteria and Treatment
Recent EU Clinical Trials:Randomized, double-blind, placebo-controlled, two way crossover, single centre study evaluating the acute and chronic effect of clonazepam on cognitive tests and patient-reported outcome measures in patients with ARID1B-related intellectual disability.
Recent NIPH Clinical Trials:A randomized, double-blind, placebo-controlled trial on the drug treatment on sleep bruxism
Description Clonazepam is a first-generation antiepileptic drug (AED) known under the proprietary brand name of Rivotril? (Roche, Basel) in the UK and Klonopin? (Roche, Basel) in the USA. Clonazepam (Item No. 14263) is an analytical reference material categorized as a benzodiazepine. Clonazepam is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.
Indications Epilepsy: monotherapy and adjunctive therapy of focal and generalized seizures. Recommendations summarized from NICE (2012) Seizure types: on referral to tertiary care (absence seizures, myoclonic seizures). Epilepsy types: on referral to tertiary care (absence syndromes, juvenile myoclonic epilepsy, idiopathic generalized epilepsy).
Uses Antiepileptic agent with anxiolytic and antimanic properties. Anticonvulsant. This is a controlled substance (depressant)
Therapeutic Function Anticonvulsant
Clinical Use Benzodiazepine: Anticonvulsant Anxiolytic Restless leg syndrome
Drug interactions Potentially hazardous interactions with other drugs Antibacterials: metabolism possibly increased by rifampicin. Antipsychotics: increased sedative effects; increased risk of hypotension, bradycardia and respiratory depression with parenteral clonazepam and IM olanzapine; risk of serious adverse effects in combination with clozapine. Antivirals: concentration possibly increased by ritonavir. Disulfiram: metabolism inhibited, increased sedative effects. Sodium oxybate: enhanced effects of sodium oxybate - avoid.

Technology Process of Clonazepam

There total 14 articles about Clonazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%