(E)-2-(4-(2-(2-(N-ethylmethylsulfonarnido)pyridin-3-yl)vinyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-methylbenzamide

Base Information

Chemical Name:(E)-2-(4-(2-(2-(N-ethylmethylsulfonarnido)pyridin-3-yl)vinyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-methylbenzamide
CAS No.:1372263-21-2
Molecular Formula:C₃₀H₃₉N₇O₄SSi
Molecular Weight:621.836
Hs Code.:

(E)-2-(4-(2-(2-(N-ethylmethylsulfonarnido)pyridin-3-yl)vinyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-methylbenzamide

Synonyms:(E)-2-(4-(2-(2-(N-ethylmethylsulfonarnido)pyridin-3-yl)vinyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-methylbenzamide

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Chemical Property of (E)-2-(4-(2-(2-(N-ethylmethylsulfonarnido)pyridin-3-yl)vinyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-methylbenzamide

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Technology Process of (E)-2-(4-(2-(2-(N-ethylmethylsulfonarnido)pyridin-3-yl)vinyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-methylbenzamide

There total 9 articles about (E)-2-(4-(2-(2-(N-ethylmethylsulfonarnido)pyridin-3-yl)vinyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372263-20-1
(E)-N-(3-(2-(2-chloro-7-((2-(trimethylsilyl)ethoxy)rnethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)vinyl)pyridin-2-yl)-N-ethylmethanesulfonamide

: 87-25-2
2-ethoxycarbonylaniline

: 1372263-21-2
(E)-2-(4-(2-(2-(N-ethylmethylsulfonarnido)pyridin-3-yl)vinyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-methylbenzamide

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 105 ℃; for 16.083h; Inert atmosphere;

Reference yield:

: 90213-66-4
2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

: 1372263-21-2
(E)-2-(4-(2-(2-(N-ethylmethylsulfonarnido)pyridin-3-yl)vinyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2: tri-n-butyl(vinyl)tin / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 6 h / Inert atmosphere; Reflux

3: sodium hydrogencarbonate; tetrabutylammomium bromide / palladium diacetate / N,N-dimethyl-formamide / 18 h / 90 °C

4: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16.08 h / 105 °C / Inert atmosphere

With tri-n-butyl(vinyl)tin; tetrabutylammomium bromide; sodium hydride; sodium hydrogencarbonate; caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 4: Buchwald-Hartwig coupling;

Reference yield:

: 84955-31-7
4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine

: 1372263-21-2
(E)-2-(4-(2-(2-(N-ethylmethylsulfonarnido)pyridin-3-yl)vinyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C

1.2: 2 h / 0 - 80 °C

1.3: pH 8

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.1: tri-n-butyl(vinyl)tin / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 6 h / Inert atmosphere; Reflux

4.1: sodium hydrogencarbonate; tetrabutylammomium bromide / palladium diacetate / N,N-dimethyl-formamide / 18 h / 90 °C

5.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16.08 h / 105 °C / Inert atmosphere

With hydrogenchloride; tri-n-butyl(vinyl)tin; tetrabutylammomium bromide; sodium hydride; sodium hydrogencarbonate; caesium carbonate; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; 5.1: Buchwald-Hartwig coupling;