2-{[4-((E)-2-{2-[ethyl(methylsulfonyl)amino]pyridin-3-yl}vinyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-methylbenzamide

Base Information

Chemical Name:2-{[4-((E)-2-{2-[ethyl(methylsulfonyl)amino]pyridin-3-yl}vinyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-methylbenzamide
CAS No.:1372263-17-6
Molecular Formula:C₂₄H₂₅N₇O₃S
Molecular Weight:491.574
Hs Code.:

Synonyms:2-{[4-((E)-2-{2-[ethyl(methylsulfonyl)amino]pyridin-3-yl}vinyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-methylbenzamide

Suppliers and Price of 2-{[4-((E)-2-{2-[ethyl(methylsulfonyl)amino]pyridin-3-yl}vinyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-methylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-{[4-((E)-2-{2-[ethyl(methylsulfonyl)amino]pyridin-3-yl}vinyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-methylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-{[4-((E)-2-{2-[ethyl(methylsulfonyl)amino]pyridin-3-yl}vinyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-methylbenzamide

There total 10 articles about 2-{[4-((E)-2-{2-[ethyl(methylsulfonyl)amino]pyridin-3-yl}vinyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372263-21-2
(E)-2-(4-(2-(2-(N-ethylmethylsulfonarnido)pyridin-3-yl)vinyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-N-methylbenzamide

: 1372263-17-6
2-{[4-((E)-2-{2-[ethyl(methylsulfonyl)amino]pyridin-3-yl}vinyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-methylbenzamide

Guidance literature:: With tetrabutyl ammonium fluoride; ethylenediamine; In tetrahydrofuran; at 80 ℃; Inert atmosphere; Sealed tube;

Reference yield:

: 90213-66-4
2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

: 1372263-17-6
2-{[4-((E)-2-{2-[ethyl(methylsulfonyl)amino]pyridin-3-yl}vinyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2: tri-n-butyl(vinyl)tin / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 6 h / Inert atmosphere; Reflux

3: sodium hydrogencarbonate; tetrabutylammomium bromide / palladium diacetate / N,N-dimethyl-formamide / 18 h / 90 °C

4: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16.08 h / 105 °C / Inert atmosphere

5: ethylenediamine; tetrabutyl ammonium fluoride / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube

With tri-n-butyl(vinyl)tin; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; sodium hydride; sodium hydrogencarbonate; caesium carbonate; ethylenediamine; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 4: Buchwald-Hartwig coupling;

Reference yield:

: 84955-31-7
4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine

: 1372263-17-6
2-{[4-((E)-2-{2-[ethyl(methylsulfonyl)amino]pyridin-3-yl}vinyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-N-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C

1.2: 2 h / 0 - 80 °C

1.3: pH 8

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.1: tri-n-butyl(vinyl)tin / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 6 h / Inert atmosphere; Reflux

4.1: sodium hydrogencarbonate; tetrabutylammomium bromide / palladium diacetate / N,N-dimethyl-formamide / 18 h / 90 °C

5.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16.08 h / 105 °C / Inert atmosphere

6.1: ethylenediamine; tetrabutyl ammonium fluoride / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; tri-n-butyl(vinyl)tin; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; sodium hydride; sodium hydrogencarbonate; caesium carbonate; ethylenediamine; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; 5.1: Buchwald-Hartwig coupling;