1,3-dihydro-1-(2'-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one

Base Information

• Chemical Name: 1,3-dihydro-1-(2'-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one
• CAS No.: 145084-43-1
• Molecular Formula: C₂₄H₂₀N₂O₂
• Molecular Weight: 368.435
• Mol file: 145084-43-1.mol

Synonyms:1,3-dihydro-1-(2'-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one

Chemical Property of 1,3-dihydro-1-(2'-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-dihydro-1-(2'-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one

There total 2 articles about 1,3-dihydro-1-(2'-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-bromo-1-o-tolylethanone (51012-65-8) + 2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one (2898-08-0) → 1,3-dihydro-1-(2'-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one (145084-43-1)

Guidance literature:

With sodium hydroxide; Aliquat 336; In toluene; for 6h; Ambient temperature;

DOI:10.1248/cpb.43.2159

Reference yield:

ethyl acetate n-hexane + Aliquat 336 (5137-55-3,76925-99-0) + 2-bromo-1-o-tolylethanone (51012-65-8) + 2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one (2898-08-0) → 1,3-dihydro-1-(2'-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one (145084-43-1)

Guidance literature:

With sodium hydroxide; In water; toluene;

Reference yield:

1,3-dihydro-1-(2'-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one (145084-43-1) → 1-[(R)-2-Oxo-1-(2-oxo-2-o-tolyl-ethyl)-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-3-p-tolyl-urea

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) t-BuOK, 2.) i-AmONO / 1.) toluene, -20 deg C, 45 min, 2.) toluene, from -20 to -15 deg C, 2 h

2: 70 percent / H₂ / 5percent Ru/C / methanol / 60 °C / 6080 Torr

4: 91 percent / tetrahydrofuran / 4 h / Ambient temperature

With potassium tert-butylate; hydrogen; isopentyl nitrite; Ru-carbon; In tetrahydrofuran; methanol;

DOI:10.1248/cpb.43.2159

upstream raw materials:

2-bromo-1-o-tolylethanone

2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one

Aliquat 336

Downstream raw materials:

1-(2-Oxo-2-o-tolyl-ethyl)-5-phenyl-1H-benzo[e][1,4]diazepine-2,3-dione 3-oxime

(RS)-3-amino-1,3-dihydro-1-(2-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one

(S)-3-amino-1,3-dihydro-1-(2-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one

(R)-3-amino-1,3-dihydro-1-(2-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one