51012-65-8

Basic information

• Product Name: 2'-METHYLPHENACYL BROMIDE
• Synonyms: 2'-METHYLPHENACYL BROMIDE;2-METHYLPHENACYL BROMIDE;AKOS BBS-00004007;2-bromo-2-methylacetophenone;2-Bromo-1-o-tolyl-ethanone;2-bromo-1-(2-methylphenyl)ethanone;2-Bromo-2'-methylacetophenone, 2-Bromo-1-(2-methylphenyl)ethan-1-one, 2-Bromo-1-(o-tolyl)ethan-1-one;2-Methyl phenycyl Bromide
• CAS NO: 51012-65-8
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213.07
• Mol File: 51012-65-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 82
• Flash Point: 69.85 °C
• Appearance: /
• Density: 1.416 g/cm³
• Vapor Pressure: 0.015mmHg at 25°C
• Refractive Index: 1.5790 to 1.5830
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility: Slightly soluble in water.
• Sensitive: Lachrymatory
• CAS DataBase Reference: 2'-METHYLPHENACYL BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-METHYLPHENACYL BROMIDE(51012-65-8)
• EPA Substance Registry System: 2'-METHYLPHENACYL BROMIDE(51012-65-8)

Safety Data

• Hazard Codes: Xi
• RIDADR: UN 2810 6.1/PG III
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 51012-65-8(Hazardous Substances Data)

Usage

Uses

2-Bromo-2'-methylacetophenone is an aromatic building block for proteomics research.

InChI:InChI=1/C9H9BrO/c1-7-4-2-3-5-8(7)9(11)6-10/h2-5H,6H2,1H3

Upstream product

• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 106-38-7 para-bromotoluene 
• 75-36-5 acetyl chloride 
• 933-88-0 ortho-toluoyl chloride 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 577-16-2 2-Methylacetophenone 
• 611-15-4 1-methyl-2-vinyl-benzene 

Downstream Products

• 23711-37-7 2-(1-pyridinium)-1-(o-tolyl)ethanone bromide 
• 1352633-48-7 (R)-1-(2-oxo-2-o-tolylethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane bromide 
• 1240949-48-7 5-(o-tolyl)-1H-pyrrole-3-carbonitrile 
• 1355616-82-8 2,2'-disulfanediylbis[5-(2-methylphenyl)-1H-pyrrole-3-carbonitrile] 
• 1240949-62-5 5-(2-methylphenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbonitrile 
• 1240949-61-4 C₁₉H₁₄N₂OS 
• 1240948-74-6 2-(2-oxo-2-(o-tolyl)ethyl)malononitrile 
• 1394017-58-3 2-(3-(2-oxo-2-o-tolylethylthio)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-4-yl)isoindoline-1,3-dione 
• 209219-89-6 1-(2-toluoylmethyl)-2-oxo-3-amino-5-(adamantan-1-yl)carbonyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine 
• 209217-95-8 1-[1-(2-toluoylmethyl)-2-oxo-5-pivaloyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]-3-(3-methylphenyl)urea 
• 209218-53-1 1-[1-(2-toluoylmethyl)-2-oxo-5-pivaloyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]-3-[3-(N,N-dimethylamino)phenyl]urea 
• 209218-59-7 1-[1-(2-toluoylmethyl)-2-oxo-5-pivaloyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]-3-(3-methoxycarbonylphenyl)urea 
• 209219-06-7 3-[3-[1-(2-toluoylmethyl)-2-oxo-5-(3-methyl-2-butenoyl)-8-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]ureido]benzoic acid 
• 209222-39-9 1-[1-(2-toluoylmethyl)-2-oxo-5-(3-methyl-2-butenoyl)-8-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]-3-(3-ethoxycarbonylphenyl)urea 

Relevant articles and documents

Facile Synthesis of α-Haloketones by Aerobic Oxidation of Olefins Using KX as Nonhazardous Halogen Source

An operationally simple and safe synthesis of α-haloketones using KBr and KCl as nonhazardous halogen sources is reported. It involves an iron-catalysed reaction of alkenes with KBr/KCl using O2 as terminal oxidant under the irradiation of visible-light. This strategy avoids the risks associated with handling halo-contained electrophiles (Cl2, Br2, NCS, NBS). The process is tolerant to several functional groups, and extended to a range of substituted styrenes in up to 89% yield. A radical reaction pathway is proposed based on control experiments and spectroscopy studies.

1,3-Dibromo-5,5-dimethylhydantoin (DBH) mediated one-pot syntheses of α-bromo/amino ketones from alkenes in water

α-Bromo ketones are versatile intermediates of high practical utility. Traditional approaches to these compounds are restricted to a relatively hazardous/complex reagent combination, a long reaction time, the use of non-environmentally friendly solvents, or a limited substrate scope. Herein, we describe the development of a new methodology for the preparation of α-bromo ketones from alkenes using 1,3-dibromo-5,5-dimethylhydantoin (DBH) as a bromine source and an oxidant simultaneously. This easy to carry out two-step one-pot protocol proceeds in water and provides high yield of a great variety of α-bromo ketones. Addition of an amine to the intermediate α-bromo ketone further enables the preparation of α-amino ketones in a one-pot sequence.

ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF

The present invention relates to alkaloid aminoester compounds which act as muscarinic receptor antagonists, processes for their preparation, compositions comprising them, and therapeutic uses thereof.