2-Benzyloxycarbonyl-5-(2-benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-4-oxo-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanedioic acid 1-benzyl ester 6-tert-butyl ester

Base Information

• Chemical Name: 2-Benzyloxycarbonyl-5-(2-benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-4-oxo-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanedioic acid 1-benzyl ester 6-tert-butyl ester
• CAS No.: 67354-43-2
• Molecular Formula: C₄₁H₄₄Cl₃N₃O₁₄
• Molecular Weight: 909.171
• Mol file: 67354-43-2.mol

Synonyms:2-Benzyloxycarbonyl-5-(2-benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-4-oxo-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanedioic acid 1-benzyl ester 6-tert-butyl ester

Chemical Property of 2-Benzyloxycarbonyl-5-(2-benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-4-oxo-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanedioic acid 1-benzyl ester 6-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzyloxycarbonyl-5-(2-benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-4-oxo-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanedioic acid 1-benzyl ester 6-tert-butyl ester

There total 6 articles about 2-Benzyloxycarbonyl-5-(2-benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-4-oxo-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanedioic acid 1-benzyl ester 6-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

mono-tert-butyl malonate (40052-13-9) → 2-Benzyloxycarbonyl-5-(2-benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-4-oxo-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanedioic acid 1-benzyl ester 6-tert-butyl ester (67354-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: EEDQ / tetrahydrofuran

2: (i) nBuLi, Et₂O, hexane, (ii) /BRN= 2686283/

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In tetrahydrofuran;

DOI:10.1016/S0040-4020(01)93609-9

Reference yield:

N-(2,2,2-Trichlorethoxycarbonyl)-aminomalonsaeuredibenzylester (67354-46-5) → 2-Benzyloxycarbonyl-5-(2-benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-4-oxo-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanedioic acid 1-benzyl ester 6-tert-butyl ester (67354-43-2)

Guidance literature:

Multi-step reaction with 4 steps

1: (i) NaH, DMF, (ii) /BRN= 1753006/

2: TsOH / acetic acid

3: SOCl₂ / CHCl₃

4: (i) nBuLi, Et₂O, hexane, (ii) /BRN= 2686283/

With thionyl chloride; toluene-4-sulfonic acid; In chloroform; acetic acid;

DOI:10.1016/S0040-4020(01)93609-9

Reference yield:

2-Benzyloxycarbonyl-N-(2,2,2-trichlorethoxycarbonyl)-asparaginsaeure-O1-benzyl-O4-tert-butylester (67354-47-6) → 2-Benzyloxycarbonyl-5-(2-benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-4-oxo-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanedioic acid 1-benzyl ester 6-tert-butyl ester (67354-43-2)

Guidance literature:

Multi-step reaction with 3 steps

1: TsOH / acetic acid

2: SOCl₂ / CHCl₃

3: (i) nBuLi, Et₂O, hexane, (ii) /BRN= 2686283/

With thionyl chloride; toluene-4-sulfonic acid; In chloroform; acetic acid;

DOI:10.1016/S0040-4020(01)93609-9

upstream raw materials:

N³-Benzyloxycarbonyl-N²-(O³-tert-butylmalonyl)-2,3-diaminopropionsaeuremethylester

2-Chlorocarbonylmethyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-malonic acid dibenzyl ester

mono-tert-butyl malonate

N-(2,2,2-Trichlorethoxycarbonyl)-aminomalonsaeuredibenzylester

Downstream raw materials:

2-[3-(2-Benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-2-oxo-propyl]-2-(2,2,2-trichloro-ethoxycarbonylamino)-malonic acid dibenzyl ester