2-[3-(2-Benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-2-oxo-propyl]-2-(2,2,2-trichloro-ethoxycarbonylamino)-malonic acid dibenzyl ester

Base Information

Chemical Name:2-[3-(2-Benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-2-oxo-propyl]-2-(2,2,2-trichloro-ethoxycarbonylamino)-malonic acid dibenzyl ester
CAS No.:67354-44-3
Molecular Formula:C₃₆H₃₆Cl₃N₃O₁₂
Molecular Weight:809.054
Hs Code.:

2-[3-(2-Benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-2-oxo-propyl]-2-(2,2,2-trichloro-ethoxycarbonylamino)-malonic acid dibenzyl ester

Synonyms:

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Chemical Property of 2-[3-(2-Benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-2-oxo-propyl]-2-(2,2,2-trichloro-ethoxycarbonylamino)-malonic acid dibenzyl ester

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Technology Process of 2-[3-(2-Benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-2-oxo-propyl]-2-(2,2,2-trichloro-ethoxycarbonylamino)-malonic acid dibenzyl ester

There total 9 articles about 2-[3-(2-Benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-2-oxo-propyl]-2-(2,2,2-trichloro-ethoxycarbonylamino)-malonic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67354-48-7
2-Benzyloxycarbonyl-N-(2,2,2-trichlorethoxycarbonyl)-asparaginsaeure-O¹-benzylester

: 67354-44-3
2-[3-(2-Benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-2-oxo-propyl]-2-(2,2,2-trichloro-ethoxycarbonylamino)-malonic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / CHCl₃

2: (i) nBuLi, Et₂O, hexane, (ii) /BRN= 2686283/, (iii) H₂O

3: (i) 1-hydroxy-benzotriazole, THF, (ii) DCC

With thionyl chloride; In chloroform;
DOI:10.1016/S0040-4020(01)93609-9

Reference yield:

: 67354-49-8
2-Chlorocarbonylmethyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-malonic acid dibenzyl ester

: 67354-44-3
2-[3-(2-Benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-2-oxo-propyl]-2-(2,2,2-trichloro-ethoxycarbonylamino)-malonic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: (i) nBuLi, Et₂O, hexane, (ii) /BRN= 2686283/, (iii) H₂O

2: (i) 1-hydroxy-benzotriazole, THF, (ii) DCC

DOI:10.1016/S0040-4020(01)93609-9

Reference yield:

: 67354-47-6
2-Benzyloxycarbonyl-N-(2,2,2-trichlorethoxycarbonyl)-asparaginsaeure-O¹-benzyl-O⁴-tert-butylester

: 67354-44-3
2-[3-(2-Benzyloxycarbonylamino-1-methoxycarbonyl-ethylcarbamoyl)-2-oxo-propyl]-2-(2,2,2-trichloro-ethoxycarbonylamino)-malonic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: TsOH / acetic acid

2: SOCl₂ / CHCl₃

3: (i) nBuLi, Et₂O, hexane, (ii) /BRN= 2686283/, (iii) H₂O

4: (i) 1-hydroxy-benzotriazole, THF, (ii) DCC

With thionyl chloride; toluene-4-sulfonic acid; In chloroform; acetic acid;
DOI:10.1016/S0040-4020(01)93609-9