N⁶-benzoyl-3'-deoxyadenylyl-<2'-P-2-(p-nitrophenyl)ethyl)>-> 5'>-N⁶-benzoyl-2'-O-<(tert-butyldimethyl)silyl>-3'-deoxyadenosine

Base Information

• Chemical Name: N⁶-benzoyl-3'-deoxyadenylyl-<2'-P-2-(p-nitrophenyl)ethyl)>-> 5'>-N⁶-benzoyl-2'-O-<(tert-butyldimethyl)silyl>-3'-deoxyadenosine
• CAS No.: 115196-56-0
• Molecular Formula: C₄₈H₅₄N₁₁O₁₂PSi
• Molecular Weight: 1036.08

Synonyms:N⁶-benzoyl-3'-deoxyadenylyl-<2'-P-2-(p-nitrophenyl)ethyl)>-> 5'>-N⁶-benzoyl-2'-O-<(tert-butyldimethyl)silyl>-3'-deoxyadenosine

Chemical Property of N⁶-benzoyl-3'-deoxyadenylyl-<2'-P-2-(p-nitrophenyl)ethyl)>-> 5'>-N⁶-benzoyl-2'-O-<(tert-butyldimethyl)silyl>-3'-deoxyadenosine

Chemical Property:

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• Pictogram(s):  
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Useful:

Technology Process of N⁶-benzoyl-3'-deoxyadenylyl-<2'-P-2-(p-nitrophenyl)ethyl)>-> 5'>-N⁶-benzoyl-2'-O-<(tert-butyldimethyl)silyl>-3'-deoxyadenosine

There total 12 articles about N⁶-benzoyl-3'-deoxyadenylyl-<2'-P-2-(p-nitrophenyl)ethyl)>-> 5'>-N⁶-benzoyl-2'-O-<(tert-butyldimethyl)silyl>-3'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N6-benzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenylyl-<2'-P-(2-(p-nitrophenyl)ethyl)>-> 5'>-N6-benzoyl-2'-O-<(tert-butyldimethyl)silyl>-3'-deoxyadenosine (115196-54-8) → N6-benzoyl-3'-deoxyadenylyl-<2'-P-2-(p-nitrophenyl)ethyl)>-> 5'>-N6-benzoyl-2'-O-<(tert-butyldimethyl)silyl>-3'-deoxyadenosine (115196-56-0)

Guidance literature:

With trifluoroacetic acid; In chloroform; for 25h; Ambient temperature;

DOI:10.1002/hlca.19870700808

Reference yield:

N-(9-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (76902-49-3) → N6-benzoyl-3'-deoxyadenylyl-<2'-P-2-(p-nitrophenyl)ethyl)>-> 5'>-N6-benzoyl-2'-O-<(tert-butyldimethyl)silyl>-3'-deoxyadenosine (115196-56-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 81 percent / pyridine / methanol / 24 h / Ambient temperature; the more 30 min

2: pyridine / 0.5 h

3: 88 percent / pyridine / 2.5 h / 2 °C

4: 96 percent / p-nitrobenzaldehyde oxime / dioxane; H₂O / 0.5 h / Ambient temperature; then 1 h.

5: 82 percent / NTPST / pyridine / 21 h / Ambient temperature

6: 81 percent / CF₃COOH (1percent) / CHCl₃ / 25 h / Ambient temperature

With pyridine; trifluoroacetic acid; 4-nitrobenzaldehyde oxime; In 1,4-dioxane; pyridine; methanol; chloroform; water;

DOI:10.1002/hlca.19870700808

Reference yield:

N6-benzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine (76885-92-2) → N6-benzoyl-3'-deoxyadenylyl-<2'-P-2-(p-nitrophenyl)ethyl)>-> 5'>-N6-benzoyl-2'-O-<(tert-butyldimethyl)silyl>-3'-deoxyadenosine (115196-56-0)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / 0.5 h

2: 88 percent / pyridine / 2.5 h / 2 °C

3: 96 percent / p-nitrobenzaldehyde oxime / dioxane; H₂O / 0.5 h / Ambient temperature; then 1 h.

4: 82 percent / NTPST / pyridine / 21 h / Ambient temperature

5: 81 percent / CF₃COOH (1percent) / CHCl₃ / 25 h / Ambient temperature

With trifluoroacetic acid; 4-nitrobenzaldehyde oxime; In 1,4-dioxane; pyridine; chloroform; water;

DOI:10.1002/hlca.19870700808

upstream raw materials:

N⁶-benzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenylyl-<2'-P-(2-(p-nitrophenyl)ethyl)>-> 5'>-N⁶-benzoyl-2'-O-<(tert-butyldimethyl)silyl>-3'-deoxyadenosine

2-(4-nitrophenyl)ethanol

N-(9-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

N⁶-benzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine

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