N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-diazoacetamide

Base Information

Chemical Name:N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-diazoacetamide
CAS No.:1083077-92-2
Molecular Formula:C₂₄H₃₂N₄O₃SSi₂
Molecular Weight:512.78
Hs Code.:

Synonyms:N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-diazoacetamide

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Chemical Property of N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-diazoacetamide

Chemical Property:

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Technology Process of N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-diazoacetamide

There total 6 articles about N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-diazoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-acetyl-α-diazoacetamide

: 1083077-92-2
N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-diazoacetamide

Guidance literature:: With potassium hydroxide; In water; acetonitrile;
DOI:10.1039/c2ob25103e

Reference yield:

: 19005-93-7
1H-indol-2-ylcarboxaldehyde

: 1083077-92-2
N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-diazoacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: diethyl ether / 20 °C / Molecular sieve; Inert atmosphere

2: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C / Inert atmosphere

3: dmap / tetrahydrofuran / 1.67 h / 0 - 20 °C / Inert atmosphere

4: 1,8-diazabicyclo[5.4.0]undec-7-ene; Methanesulfonyl azide / acetonitrile / 2 h / 0 - 20 °C / Inert atmosphere

5: potassium hydroxide / water; acetonitrile

With dmap; sodium tetrahydroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; Methanesulfonyl azide; potassium hydroxide; In tetrahydrofuran; methanol; diethyl ether; water; acetonitrile;
DOI:10.1039/c2ob25103e

Reference yield:

: C₂₆H₃₆N₂O₄SSi₂

: 1083077-92-2
N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-diazoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; Methanesulfonyl azide / acetonitrile / 2 h / 0 - 20 °C / Inert atmosphere

2: potassium hydroxide / water; acetonitrile

With 1,8-diazabicyclo[5.4.0]undec-7-ene; Methanesulfonyl azide; potassium hydroxide; In water; acetonitrile;
DOI:10.1039/c2ob25103e