Cefazedone sodium salt

Base Information

• Chemical Name: Cefazedone sodium salt
• CAS No.: 63521-15-3
• Molecular Formula: C18H15 Cl2 N5 O5 S3 . Na
• Molecular Weight: 570.433
• Mol file: 63521-15-3.mol

Synonyms:5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(3,5-dichloro-4-oxo-1(4H)-pyridinyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-,monosodium salt, (6R,7R)- (9CI); 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(3,5-dichloro-4-oxo-1(4H)-pyridinyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-,monosodium salt, (6R-trans)-; Cefazedone sodium; Cefazedone sodium salt; EMD30087; NSC 304118; Refosporin

Chemical Property of Cefazedone sodium salt

Chemical Property:

• PSA: 216.16000
• Density: 1.78g/cm3
• LogP: 0.84000

Purity/Quality:

99.9% ^*data from raw suppliers

CEFAZEDONE SODIUM SALT 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Therapeutic Function: Antibiotic

Technology Process of Cefazedone sodium salt

There total 9 articles about Cefazedone sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

C10H7Cl2N3O2S2 + 7-Aminocephalosporanic acid (957-68-6) → (6R,7R)-3-[[(5-methyl-1,3,4-thiadiazolyl-2-yl)thio]methyl]-7-[2-(3,5-dichloro-4-pyridone-1-acetylamido)]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt (63521-15-3)

Guidance literature:

C₁₀H₇Cl₂N₃O₂S₂; 7-Aminocephalosporanic acid; With sodium hydroxide; In water; acetonitrile; at 30 ℃; for 3h;

With sodium hydrogencarbonate; pyrographite; In water; acetonitrile; at 30 - 40 ℃; for 2h; pH=8;

Reference yield: 96.6%

3,5-Dichlor-4-pyridon-1-yl-ethylacetat (70149-51-8) + (6R,7R)-7-amino-3-(5-methyl-1,3,4-thiadiazol-2-ylthiomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (30246-33-4) → (6R,7R)-3-[[(5-methyl-1,3,4-thiadiazolyl-2-yl)thio]methyl]-7-[2-(3,5-dichloro-4-pyridone-1-acetylamido)]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt (63521-15-3)

Guidance literature:

3,5-Dichlor-4-pyridon-1-yl-ethylacetat; (6R,7R)-7-amino-3-(5-methyl-1,3,4-thiadiazol-2-ylthiomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; With trimethylaluminum; In hexane; acetonitrile; at 30 - 35 ℃; for 5h;

With sodium hydrogencarbonate; In water; for 1h; pH=7; Solvent;

Reference yield: 95.2%

cefazedone (56187-47-4) → (6R,7R)-3-[[(5-methyl-1,3,4-thiadiazolyl-2-yl)thio]methyl]-7-[2-(3,5-dichloro-4-pyridone-1-acetylamido)]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt (63521-15-3)

Guidance literature:

cefazedone; With triethylamine; In methanol; at 0 - 10 ℃; for 0.5h;

With sodium 2-ethylhexanoic acid; In methanol; acetone; at 0 - 10 ℃; for 3.5h;

upstream raw materials:

7-aminocephalosporanic acid

7-phenylacetylamino-3-(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester

(6R,7R)-7-amino-3-(5-methyl-1,3,4-thiadiazol-2-ylthiomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

3,5-Dichlor-4-pyridon-1-yl-ethylacetat

Refernces

• 1、 -. "Synthesis process of cefazedone sodium". Paragraph 0023-0040. . Retrieved 2020/06/09.
• 2、 -. "Preparation technology of cefazedone sodium". . . Retrieved 2019/05/08.