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63521-15-3

Basic Information
CAS No.: 63521-15-3
Name: Cefazedone sodium salt
Article Data: 8
Molecular Structure:
Molecular Structure of 63521-15-3 (Cefazedone sodium salt)
Formula: C18H15 Cl2 N5 O5 S3 . Na
Molecular Weight: 570.433
Synonyms: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(3,5-dichloro-4-oxo-1(4H)-pyridinyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-,monosodium salt, (6R,7R)- (9CI); 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(3,5-dichloro-4-oxo-1(4H)-pyridinyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-,monosodium salt, (6R-trans)-; Cefazedone sodium; Cefazedone sodium salt; EMD30087; NSC 304118; Refosporin
EINECS: 264-293-9
Density: 1.78g/cm3
Safety: Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. Used as an antibacterial agent. When heated to decomposition, it emits very toxic fumes of Cl, NOx, Na2O, and SOx.
PSA: 216.16000
LogP: 0.84000
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Chemistry

IUPAC Name: Sodium (6R,7R)-7-[[2-(3,5-dichloro-4-oxopyridin-1-yl)acetyl]amino]-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Synonyms: Sodium (6R-trans)-7-[[(3,5-dichloro-4-oxo-1(4H)-pyridyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;Cefazedone, sodium salt ; Sodium (6R,7R)-7-[[(3,5-dichloro-4-oxo-1(4H)-pyridyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate ; (6R,7R)-7-[[2-(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
Molecular Structure of Refosporen (CAS NO.63521-15-3) :
Molecular Formula of Refosporen (CAS NO.63521-15-3) : C18H14Cl2N5NaO5S3
Molecular Weight of Refosporen (CAS NO.63521-15-3) : 570.42
CAS NO: 63521-15-3
EINECS: 264-293-9

Uses

 Refosporen (CAS NO.63521-15-3) has a significant effect of broad-spectrum antibacterial.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 3gm/kg (3000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
mouse LD50 intramuscular > 10gm/kg (10000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
mouse LD50 intravenous 6800mg/kg (6800mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
rabbit LD50 intravenous 3200mg/kg (3200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
rat LD50 intramuscular > 10gm/kg (10000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
rat LD50 intravenous 4225mg/kg (4225mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.

 

Safety Profile

Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. Used as an antibacterial agent. When heated to decomposition, it emits very toxic fumes of Cl, NOx, Na2O, and SOx.