N^α-(tert-butyloxycarbonyl)-N^ε-10-methylpteroyl)L-glutamyl>-γ-L-lysyl-N'-(benzyloxycarbonyl)-L-lysine

Base Information

• Chemical Name: N^α-(tert-butyloxycarbonyl)-N^ε-10-methylpteroyl)L-glutamyl>-γ-L-lysyl-N'-(benzyloxycarbonyl)-L-lysine
• CAS No.: 89637-92-3
• Molecular Formula: C₄₅H₆₀N₁₂O₁₁
• Molecular Weight: 945.045

Synonyms:N^α-(tert-butyloxycarbonyl)-N^ε-10-methylpteroyl)L-glutamyl>-γ-L-lysyl-N'-(benzyloxycarbonyl)-L-lysine

Chemical Property of N^α-(tert-butyloxycarbonyl)-N^ε-10-methylpteroyl)L-glutamyl>-γ-L-lysyl-N'-(benzyloxycarbonyl)-L-lysine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-(tert-butyloxycarbonyl)-N^ε-10-methylpteroyl)L-glutamyl>-γ-L-lysyl-N'-(benzyloxycarbonyl)-L-lysine

There total 8 articles about N^α-(tert-butyloxycarbonyl)-N^ε-10-methylpteroyl)L-glutamyl>-γ-L-lysyl-N'-(benzyloxycarbonyl)-L-lysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Nα-(tert-butyloxycarbonyl)-Nε-10-methylpteroyl)L-glutamyl>-γ-L-lysyl-N'-(benzyloxycarbonyl)-L-lysine benzyl(α-Glu)methyl(Lys) ester (89637-91-2) → Nα-(tert-butyloxycarbonyl)-Nε-10-methylpteroyl)L-glutamyl>-γ-L-lysyl-N'-(benzyloxycarbonyl)-L-lysine (89637-92-3)

Guidance literature:

With barium dihydroxide; In ethanol; water; Ambient temperature;

DOI:10.1021/jm00373a014

Reference yield:

1-benzyl L-glutamate (13030-09-6) → Nα-(tert-butyloxycarbonyl)-Nε-10-methylpteroyl)L-glutamyl>-γ-L-lysyl-N'-(benzyloxycarbonyl)-L-lysine (89637-92-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 99 percent / Et₃N / benzene / Ambient temperature

2: 1.) diethyl phosphorocyanidate, Et₃N / 1.) DMF, overnight, RT, 2.) DMF, RT, 3 d

3: Et₃N / dimethylformamide / 0.33 h / Ambient temperature

4: dimethylformamide / Ambient temperature

5: 79 percent / diphenylphosphoryl azide, Et₃N / dimethylformamide / 0 - 20 °C

6: 86 percent / Ba(OH)2*8H₂O / ethanol; H₂O / Ambient temperature

With barium dihydroxide; diethyl cyanophosphonate; diphenylphosphoranyl azide; triethylamine; In ethanol; water; N,N-dimethyl-formamide; benzene;

DOI:10.1021/jm00373a014

Reference yield:

Boc-Lys-OH (13734-28-6) → Nα-(tert-butyloxycarbonyl)-Nε-10-methylpteroyl)L-glutamyl>-γ-L-lysyl-N'-(benzyloxycarbonyl)-L-lysine (89637-92-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / Et₃N / benzene / Ambient temperature

2: dimethylformamide / Ambient temperature

3: 79 percent / diphenylphosphoryl azide, Et₃N / dimethylformamide / 0 - 20 °C

4: 86 percent / Ba(OH)2*8H₂O / ethanol; H₂O / Ambient temperature

With barium dihydroxide; diphenylphosphoranyl azide; triethylamine; In ethanol; water; N,N-dimethyl-formamide; benzene;

DOI:10.1021/jm00373a014

upstream raw materials:

N^α-(tert-butyloxycarbonyl)-N^ε-10-methylpteroyl)L-glutamyl>-γ-L-lysyl-N'-(benzyloxycarbonyl)-L-lysine benzyl(α-Glu)methyl(Lys) ester

1-benzyl L-glutamate

Boc-Lys-OH

C₁₇H₃₈N₂O₄Si₂

Downstream raw materials:

N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine trifluoroacetate

N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine

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