2-{3-[4-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-butoxy]-2-propyl-phenoxy}-benzoic acid methyl ester

Base Information

• Chemical Name: 2-{3-[4-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-butoxy]-2-propyl-phenoxy}-benzoic acid methyl ester
• CAS No.: 1026840-64-1
• Molecular Formula: C₃₅H₃₇FO₆
• Molecular Weight: 572.674
• Mol file: 1026840-64-1.mol

Synonyms:2-{3-[4-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-butoxy]-2-propyl-phenoxy}-benzoic acid methyl ester

Chemical Property of 2-{3-[4-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-butoxy]-2-propyl-phenoxy}-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{3-[4-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-butoxy]-2-propyl-phenoxy}-benzoic acid methyl ester

There total 14 articles about 2-{3-[4-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-butoxy]-2-propyl-phenoxy}-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[2-propyl-3-[4-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]butoxy]phenoxy]-benzoic acid methyl ester (152610-03-2) → 2-{3-[4-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-butoxy]-2-propyl-phenoxy}-benzoic acid methyl ester (1026840-64-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; under 760 Torr; Ambient temperature;

DOI:10.1021/jm00022a006

Reference yield:

1,3-Dimethoxy-2-(prop-1'-yl)benzene (16929-64-9) → 2-{3-[4-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-butoxy]-2-propyl-phenoxy}-benzoic acid methyl ester (1026840-64-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 95 percent / Py*HCl / 8 h / 180 °C

2: 14 percent / copper bronze, K₂CO₃ / pyridine / 6 h / Heating

3: aq. NaOH / methanol / 48 h / Heating

4: conc. H₂SO₄ / 18 h / Heating

5: 75 percent / K₂CO₃, KI, DMSO / butan-2-one / 18 h / Heating

6: H₂ / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

With sodium hydroxide; sulfuric acid; hydrogen; pyridine hydrochloride; copper; potassium carbonate; dimethyl sulfoxide; potassium iodide; palladium on activated charcoal; In pyridine; methanol; ethyl acetate; butanone;

DOI:10.1021/jm00022a006

Reference yield:

1,3-Dimethoxybenzene (151-10-0) → 2-{3-[4-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-butoxy]-2-propyl-phenoxy}-benzoic acid methyl ester (1026840-64-1)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) n-BuLi / 1.) THF, hexane, from -70 deg C to RT, 2.) THF, hexane, RT, 18 h, b) reflux, 5 h

2: 95 percent / Py*HCl / 8 h / 180 °C

3: 14 percent / copper bronze, K₂CO₃ / pyridine / 6 h / Heating

4: aq. NaOH / methanol / 48 h / Heating

5: conc. H₂SO₄ / 18 h / Heating

6: 75 percent / K₂CO₃, KI, DMSO / butan-2-one / 18 h / Heating

7: H₂ / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

With sodium hydroxide; n-butyllithium; sulfuric acid; hydrogen; pyridine hydrochloride; copper; potassium carbonate; dimethyl sulfoxide; potassium iodide; palladium on activated charcoal; In pyridine; methanol; ethyl acetate; butanone;

DOI:10.1021/jm00022a006

upstream raw materials:

2-[2-propyl-3-[4-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]butoxy]phenoxy]-benzoic acid methyl ester

1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone

2-propyl-1,3-benzenediol

1,3-Dimethoxy-2-(prop-1'-yl)benzene