4-(3-chlorophenyl)-N'-hydroxy-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboximidamide

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Chemical Name:4-(3-chlorophenyl)-N'-hydroxy-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboximidamide
CAS No.:1616372-03-2
Molecular Formula:C₂₁H₂₄ClN₅O
Molecular Weight:397.907
Hs Code.:

Synonyms:4-(3-chlorophenyl)-N'-hydroxy-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboximidamide

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Chemical Property of 4-(3-chlorophenyl)-N'-hydroxy-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboximidamide

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Technology Process of 4-(3-chlorophenyl)-N'-hydroxy-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboximidamide

There total 6 articles about 4-(3-chlorophenyl)-N'-hydroxy-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616372-00-9
4-(3-chlorophenyl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

: 1616372-03-2
4-(3-chlorophenyl)-N'-hydroxy-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboximidamide

Guidance literature:: With hydroxylamine hydrochloride; sodium hydrogencarbonate; In ethanol; water; for 2h; Reflux;

Reference yield:

: 934-67-8,4331-54-8,13064-83-0
trans-4-methylcyclohexanecarboxylic acid

: 1616372-03-2
4-(3-chlorophenyl)-N'-hydroxy-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboximidamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane-THF / tetrahydrofuran / 9 h / 0 - 25 °C / Inert atmosphere

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 13 h / 0 - 25 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 20 h / 100 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 0.25 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl acetamide / 17 h / 115 °C / Inert atmosphere; Sealed tube

6.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol; water / 2 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; carbon tetrabromide; hydroxylamine hydrochloride; sodium hydride; sodium hydrogencarbonate; sodium carbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 3937-49-3
(trans-4-methylcyclohexyl)methanol

: 1616372-03-2
4-(3-chlorophenyl)-N'-hydroxy-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carboximidamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 13 h / 0 - 25 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 20 h / 100 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 0.25 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl acetamide / 17 h / 115 °C / Inert atmosphere; Sealed tube

5.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol; water / 2 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; hydroxylamine hydrochloride; sodium hydride; sodium hydrogencarbonate; sodium carbonate; triphenylphosphine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; mineral oil;