methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxypropanoate

Base Information

Chemical Name:methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxypropanoate
CAS No.:131066-61-0
Molecular Formula:C₂₀H₃₁N₂O₈P
Molecular Weight:458.448
Hs Code.:

Synonyms:methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxypropanoate

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Chemical Property of methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxypropanoate

Chemical Property:

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Technology Process of methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxypropanoate

There total 4 articles about methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2018-66-8
Z-Leu-OH

: 131066-61-0
methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxypropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / N-hydroxybenzotriazole (HOBT), 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide (EDC) / CH₂Cl₂ / Ambient temperature

2: H₂ / 5percent Pd/C / ethyl acetate / 5 h

3: Et₃N, 4-A molecular sieves / CH₂Cl₂ / 48 h

With 4 A molecular sieve; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/ja00001a043

Reference yield:

: 131066-57-4
methyl O--(S)-2-hydroxypropanoate

: 131066-61-0
methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxypropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 5percent Pd/C / ethyl acetate / 5 h

2: Et₃N, 4-A molecular sieves / CH₂Cl₂ / 48 h

With 4 A molecular sieve; hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/ja00001a043

Reference yield:

: 76203-93-5
methyl <(N-carbobenzoxyamino)methyl>phosphonic acid

: 131066-61-0
methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxypropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂ / 3.5 h / Ambient temperature

2: Et₃N, 4-A molecular sieves / CH₂Cl₂ / 48 h

With thionyl chloride; 4 A molecular sieve; triethylamine; In dichloromethane;
DOI:10.1021/ja00001a043