N-{2-methyl-4-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-1H-imidazol-1-yl}imidoformamide

Base Information

Chemical Name:N-{2-methyl-4-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-1H-imidazol-1-yl}imidoformamide
CAS No.:1394034-50-4
Molecular Formula:C₁₆H₁₈N₆
Molecular Weight:294.359
Hs Code.:

Synonyms:N-{2-methyl-4-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-1H-imidazol-1-yl}imidoformamide

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Chemical Property of N-{2-methyl-4-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-1H-imidazol-1-yl}imidoformamide

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Technology Process of N-{2-methyl-4-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-1H-imidazol-1-yl}imidoformamide

There total 7 articles about N-{2-methyl-4-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-1H-imidazol-1-yl}imidoformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1394034-49-1
2-methyl-4-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-1H-imidazol-1-amine

: 16694-46-5
ethyl formimidate hydrochloride

: 1394034-50-4
N-{2-methyl-4-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-1H-imidazol-1-yl}imidoformamide

Guidance literature:: In ethanol; at 75 ℃; for 92h;

Reference yield:

: 73387-56-1
1-methyl-5-(4-methylphenyl)-1H-pyrazole

: 1394034-50-4
N-{2-methyl-4-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-1H-imidazol-1-yl}imidoformamide

Guidance literature:: Multi-step reaction with 6 steps

1: N-iodo-succinimide / acetonitrile / 1 h / 85 °C

2: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 18 h / 90 °C

3: bromine; acetic acid / 2 h / 80 °C

4: sodium hydrogencarbonate / acetonitrile / 3 h / 80 °C

5: hydrogenchloride / water; methanol / 1 h / Reflux

6: ethanol / 92 h / 75 °C

With hydrogenchloride; N-iodo-succinimide; bromine; sodium hydrogencarbonate; acetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1394034-45-7
4-iodo-1-methyl-5-(4-methylphenyl)-1H-pyrazole

: 1394034-50-4
N-{2-methyl-4-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-1H-imidazol-1-yl}imidoformamide

Guidance literature:: Multi-step reaction with 5 steps

1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 18 h / 90 °C

2: bromine; acetic acid / 2 h / 80 °C

3: sodium hydrogencarbonate / acetonitrile / 3 h / 80 °C

4: hydrogenchloride / water; methanol / 1 h / Reflux

5: ethanol / 92 h / 75 °C

With hydrogenchloride; bromine; sodium hydrogencarbonate; acetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;