(S)-2-(3-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-ylcarbamoyl)isoxazol-5-yl)propan-2-yl acetate

Base Information

Chemical Name:(S)-2-(3-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-ylcarbamoyl)isoxazol-5-yl)propan-2-yl acetate
CAS No.:1297542-60-9
Molecular Formula:C₂₂H₂₂ClN₅O₄
Molecular Weight:455.901
Hs Code.:

Synonyms:(S)-2-(3-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-ylcarbamoyl)isoxazol-5-yl)propan-2-yl acetate

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Chemical Property of (S)-2-(3-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-ylcarbamoyl)isoxazol-5-yl)propan-2-yl acetate

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Technology Process of (S)-2-(3-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-ylcarbamoyl)isoxazol-5-yl)propan-2-yl acetate

There total 6 articles about (S)-2-(3-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-ylcarbamoyl)isoxazol-5-yl)propan-2-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1297539-13-9
(S)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(2-hydroxypropan-2-yl)isoxazole-3-carboxamide

: 108-24-7
acetic anhydride

: 1297542-60-9
(S)-2-(3-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-ylcarbamoyl)isoxazol-5-yl)propan-2-yl acetate

Guidance literature:: With pyridine; dmap; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 154607-01-9
4-bromo-2-chlorobenzonitrile

: 1297542-60-9
(S)-2-(3-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-ylcarbamoyl)isoxazol-5-yl)propan-2-yl acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 2.5 h / 35 °C

2.1: hydrogenchloride / ethanol / 1 h / 30 °C / Inert atmosphere

3.1: sodium hydroxide / water; methanol / 2 h / 25 °C / Inert atmosphere

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

4.2: 20 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 20 °C

6.1: dmap; pyridine / 0 - 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; dmap; di-isopropyl azodicarboxylate; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1297537-35-9
2-Chloro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzonitrile

: 1297542-60-9
(S)-2-(3-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-ylcarbamoyl)isoxazol-5-yl)propan-2-yl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / ethanol / 1 h / 30 °C / Inert atmosphere

2.1: sodium hydroxide / water; methanol / 2 h / 25 °C / Inert atmosphere

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

3.2: 20 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 20 °C

5.1: dmap; pyridine / 0 - 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; dmap; di-isopropyl azodicarboxylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;