(S)-4-tert-butoxyphenylglycine tert-butyl ester hydrochloride

Base Information

• Chemical Name: (S)-4-tert-butoxyphenylglycine tert-butyl ester hydrochloride
• CAS No.: 136057-26-6
• Molecular Formula: C₁₆H₂₅NO₃*ClH
• Molecular Weight: 315.84
• Mol file: 136057-26-6.mol

Synonyms:(S)-4-tert-butoxyphenylglycine tert-butyl ester hydrochloride

Chemical Property of (S)-4-tert-butoxyphenylglycine tert-butyl ester hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-tert-butoxyphenylglycine tert-butyl ester hydrochloride

There total 3 articles about (S)-4-tert-butoxyphenylglycine tert-butyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-N-benzyloxycarbonyl-4-tert-butoxyphenylglycine tert-butyl ester (136057-25-5) → (S)-4-tert-butoxyphenylglycine tert-butyl ester hydrochloride (136057-26-6)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; for 1h;

Reference yield:

(S)-hydroxyphenylglycine (32462-30-9) → (S)-4-tert-butoxyphenylglycine tert-butyl ester hydrochloride (136057-26-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / NaHCO₃ / H₂O / 1 h

2: 53 percent / conc. H₂SO₄ / CH₂Cl₂ / 67 h / Ambient temperature

3: 100 percent / 1) H₂, 2) HCl / 10percent Pd/C / methanol / 1 h

With hydrogenchloride; sulfuric acid; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; dichloromethane; water;

Reference yield:

(S)-N-benzyloxycarbonyl-4-hydroxyphenylglycine (26787-76-8) → (S)-4-tert-butoxyphenylglycine tert-butyl ester hydrochloride (136057-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / conc. H₂SO₄ / CH₂Cl₂ / 67 h / Ambient temperature

2: 100 percent / 1) H₂, 2) HCl / 10percent Pd/C / methanol / 1 h

With hydrogenchloride; sulfuric acid; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

upstream raw materials:

(S)-N-benzyloxycarbonyl-4-tert-butoxyphenylglycine tert-butyl ester

(S)-hydroxyphenylglycine

(S)-N-benzyloxycarbonyl-4-hydroxyphenylglycine

Downstream raw materials:

(R)-4-{3-[4-((R)-2-Azido-2-{[(S)-tert-butoxycarbonyl-(4-tert-butoxy-phenyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-phenyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

(R)-4-{3-[4-((R)-2-[(R)-2-Benzyloxycarbonylamino-2-(4-hydroxy-phenyl)-acetylamino]-2-{[(S)-tert-butoxycarbonyl-(4-tert-butoxy-phenyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-phenyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester