(S)-N-benzyloxycarbonyl-4-tert-butoxyphenylglycine tert-butyl ester

Base Information

• Chemical Name: (S)-N-benzyloxycarbonyl-4-tert-butoxyphenylglycine tert-butyl ester
• CAS No.: 136057-25-5
• Molecular Formula: C₂₄H₃₁NO₅
• Molecular Weight: 413.514
• Mol file: 136057-25-5.mol

Synonyms:(S)-N-benzyloxycarbonyl-4-tert-butoxyphenylglycine tert-butyl ester

Chemical Property of (S)-N-benzyloxycarbonyl-4-tert-butoxyphenylglycine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-benzyloxycarbonyl-4-tert-butoxyphenylglycine tert-butyl ester

There total 3 articles about (S)-N-benzyloxycarbonyl-4-tert-butoxyphenylglycine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

(S)-N-benzyloxycarbonyl-4-hydroxyphenylglycine (26787-76-8) + isobutene (115-11-7,15220-85-6) → (S)-N-benzyloxycarbonyl-4-tert-butoxyphenylglycine tert-butyl ester (136057-25-5)

Guidance literature:

With sulfuric acid; In dichloromethane; for 67h; Ambient temperature;

Reference yield:

(S)-hydroxyphenylglycine (32462-30-9) → (S)-N-benzyloxycarbonyl-4-tert-butoxyphenylglycine tert-butyl ester (136057-25-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / NaHCO₃ / H₂O / 1 h

2: 53 percent / conc. H₂SO₄ / CH₂Cl₂ / 67 h / Ambient temperature

With sulfuric acid; sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → (S)-N-benzyloxycarbonyl-4-tert-butoxyphenylglycine tert-butyl ester (136057-25-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / NaHCO₃ / H₂O / 1 h

2: 53 percent / conc. H₂SO₄ / CH₂Cl₂ / 67 h / Ambient temperature

With sulfuric acid; sodium hydrogencarbonate; In dichloromethane; water;

upstream raw materials:

(S)-N-benzyloxycarbonyl-4-hydroxyphenylglycine

isobutene

(S)-hydroxyphenylglycine

benzyl chloroformate

Downstream raw materials:

(S)-4-tert-butoxyphenylglycine tert-butyl ester hydrochloride

(R)-4-{3-[4-((R)-2-Azido-2-{[(S)-tert-butoxycarbonyl-(4-tert-butoxy-phenyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-phenyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

(R)-4-{3-[4-((R)-2-[(R)-2-Benzyloxycarbonylamino-2-(4-hydroxy-phenyl)-acetylamino]-2-{[(S)-tert-butoxycarbonyl-(4-tert-butoxy-phenyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-phenyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester