3-[4-(allyl-dimethyl-silanyl)-phenyl]-2-tert-butoxycarbonylamino-propionic acid ethyl ester

Base Information

Chemical Name:3-[4-(allyl-dimethyl-silanyl)-phenyl]-2-tert-butoxycarbonylamino-propionic acid ethyl ester
CAS No.:247566-32-1
Molecular Formula:C₂₁H₃₃NO₄Si
Molecular Weight:391.583
Hs Code.:

3-[4-(allyl-dimethyl-silanyl)-phenyl]-2-<i>tert</i>-butoxycarbonylamino-propionic acid ethyl ester

Synonyms:3-[4-(allyl-dimethyl-silanyl)-phenyl]-2-tert-butoxycarbonylamino-propionic acid ethyl ester

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Chemical Property of 3-[4-(allyl-dimethyl-silanyl)-phenyl]-2-tert-butoxycarbonylamino-propionic acid ethyl ester

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Technology Process of 3-[4-(allyl-dimethyl-silanyl)-phenyl]-2-tert-butoxycarbonylamino-propionic acid ethyl ester

There total 7 articles about 3-[4-(allyl-dimethyl-silanyl)-phenyl]-2-tert-butoxycarbonylamino-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17100-68-4
2-((4-bromobenzyl)oxy)tetrahydro-2H-pyran

: 247566-32-1
3-[4-(allyl-dimethyl-silanyl)-phenyl]-2-tert-butoxycarbonylamino-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-Buli / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran

2.1: TsOH / methanol / 16 h

3.1: CBr₄, PPh₃ / CH₂Cl₂

4.1: 71 percent / n-BuLi / tetrahydrofuran / -78 °C

5.1: 1N aq. HCl / methanol / 0.5 h

6.1: NaHCO₃ / H₂O; dioxane

With hydrogenchloride; n-butyllithium; carbon tetrabromide; sodium hydrogencarbonate; toluene-4-sulfonic acid; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1.1: Metallation / 1.2: Substitution / 2.1: Substitution / 3.1: Bromination / 4.1: Substitution / 5.1: Hydrolysis / 6.1: Substitution;
DOI:10.1021/ja991679d

Reference yield:

: 4028-23-3
Allylchlorodimethylsilane

: 247566-32-1
3-[4-(allyl-dimethyl-silanyl)-phenyl]-2-tert-butoxycarbonylamino-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-Buli / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran

2.1: TsOH / methanol / 16 h

3.1: CBr₄, PPh₃ / CH₂Cl₂

4.1: 71 percent / n-BuLi / tetrahydrofuran / -78 °C

5.1: 1N aq. HCl / methanol / 0.5 h

6.1: NaHCO₃ / H₂O; dioxane

With hydrogenchloride; n-butyllithium; carbon tetrabromide; sodium hydrogencarbonate; toluene-4-sulfonic acid; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1.1: Metallation / 1.2: Substitution / 2.1: Substitution / 3.1: Bromination / 4.1: Substitution / 5.1: Hydrolysis / 6.1: Substitution;
DOI:10.1021/ja991679d

Reference yield:

: 247566-28-5
4-allyldimethylsilylbenzyl bromide

: 247566-32-1
3-[4-(allyl-dimethyl-silanyl)-phenyl]-2-tert-butoxycarbonylamino-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / n-BuLi / tetrahydrofuran / -78 °C

2: 1N aq. HCl / methanol / 0.5 h

3: NaHCO₃ / H₂O; dioxane

With hydrogenchloride; n-butyllithium; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1: Substitution / 2: Hydrolysis / 3: Substitution;
DOI:10.1021/ja991679d