17100-68-4

Upstream product

• 873-75-6 4-bromobenzenemethanol 
• 110-87-2 3,4-dihydro-2H-pyran 
• 60-29-7 diethyl ether 
• 142-68-7 TETRAHYDROPYRANE 

Downstream Products

• 157523-08-5 2-<(p-Tetrahydropyranyloxymethyl)phenyl>-1,10-phenanthroline 
• 88139-98-4 (3S^*,4R^*)-1-(o-nitrobenzyloxycarbonyltriphenylphosphoranylidene)methyl-3-<(R^*)-1-(o-nitrobenzyloxycarbonyloxy)ethyl>-4-<4'-(2-pyranyloxymethyl)phenylcarbonyl>methyl-azetidin-2-one 
• 157523-10-9 2,9-Bis<(p-tetrahydropyranyloxymethyl)phenyl>-1,10-phenanthroline 
• 1027413-28-0 2-(4-Benzyl-benzyloxy)-tetrahydro-pyran 
• 195388-59-1 2-(4-Methylselanyl-benzyloxy)-tetrahydro-pyran 
• 195388-62-6 2-(4-Methyltellanyl-benzyloxy)-tetrahydro-pyran 
• 247566-26-3 allyl-dimethyl-[4-(tetrahydro-pyran-2-yloxymethyl)-phenyl]-silane 
• 164460-51-9 <4-<<(tetrahydro-2H-pyran-2-yl)oxy>methyl>phenyl>boronic acid 
• 1122-91-4 4-bromo-benzaldehyde 
• 873-75-6 4-bromobenzenemethanol 
• 148319-98-6 2-(4-Benzylbenzyl)benzyl bromide 
• 148319-99-7 2-<2-(4-Benzylbenzyl)benzyl>benzyl alcohol 
• 148320-00-7 2-<2-(4-Benzylbenzyl)benzyl>benzyl bromide 
• 1025981-79-6 2-[2-(4-Benzyl-benzyl)-benzyloxy]-tetrahydro-pyran 

Relevant academic research and scientific papers

Solid-supported single-component Pd(II) catalysts for polar monomer insertion copolymerization

Heterogenized representatives of neutral phosphine sulfonato Pd(II) complexes for polar monomer insertion polymerization were prepared by two different approaches. [{κ2-(P,O)-(2-anisyl)2PC 6H4SO2O}Pd(

A Benzophenone-Based Photocaging Strategy for the N7 Position of Guanosine

Selective modification of nucleobases with photolabile caging groups enables the study and control of processes and interactions of nucleic acids. Numerous positions on nucleobases have been targeted, but all involve formal substitution of a hydrogen atom with a photocaging group. Nature, however, also uses ring-nitrogen methylation, such as m7G and m1A, to change the electronic structure and properties of RNA and control biomolecular interactions essential for translation and turnover. We report that aryl ketones such as benzophenone and α-hydroxyalkyl ketone are photolabile caging groups if installed at the N7 position of guanosine or the N1 position of adenosine. Common photocaging groups derived from the ortho-nitrobenzyl moiety were not suitable. Both chemical and enzymatic methods for site-specific modification of N7G in nucleosides, dinucleotides, and RNA were developed, thereby opening the door to studying the molecular interactions of m7G and m1A with spatiotemporal control.

Highly selective tetrahydropyranylation/dehydropyranylation of alcohols and phenols using porous phenolsulfonic acid-formaldehyde resin catalyst under solvent-free condition

An efficient protocol for solvent-free chemoselective tetrahydropyranylation/depyranylation of alcohols and phenols is reported herein using mesoporous Phenolsulfonic Acid Formaldehyde Resins as a heterogeneous acid catalyst. The catalyst successfully performed chemoselective protection and deprotection reactions of a wide range of substrates ranging from primary to secondary and tertiary alcohols and also phenols. The reactions were carried out at ambient temperature under solvent-free condition (SolFC) which resulted in high yields within a very short time. FT-IR, TEM, SEM, EDS and TG-DSC analysis techniques were employed to characterize the synthesized polymeric catalyst. The chemoselective nature of our method was confirmed using 13C DEPT-135 NMR studies. The polymer catalyst was found to be recoverable even after 10th catalytic cycle without much depreciation in its activity. The heterogeneity of the catalyst was verified by hot filtration method. Good yield, energy and cost- effective method, solvent-free protocol, mild reaction conditions, no inert atmosphere, metal-free heterogeneous polymer catalyst and excellent recoverability of the catalyst are notable milestones of the reported protocol.

Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp3-sp2 Suzuki Coupling of a Benzyl Carbonate

Process development for the synthesis of a locally acting sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor, LX2761, a drug candidate for the treatment of diabetes mellitus, is described. A convergent route based on a retrosynthetic disconnection of the central diarylmethane linkage to a benzyl carbonate and a hindered arylboronic ester was designed and developed. The syntheses of these fully elaborated, late-stage crystalline intermediates are discussed, along with optimization of their union via an sp3-sp2 Suzuki-Miyaura coupling reaction. The final active pharmaceutical ingredient was isolated in high purity as its l-proline cocrystal. This process was successfully performed on a kilogram scale to support toxicology and preclinical studies.

Colored resin composition colored filter and display device

The present invention is to provide a colored resin composition with excellent heat resistance and light resistance, a color filter, and a display device. The colored resin composition contains a colorant and resin. The colorant is represented by formula

Heterogeneous acidic catalysts for the tetrahydropyranylation of alcohols and phenols in green ethereal solvents

The application of heterogeneous catalysis and green solvents to the set up of widely employed reactions is a challenge in contemporary organic chemistry. We applied such an approach to the synthesis and further conversion of tetrahydropyranyl ethers, an important class of compounds widely employed in multistep syntheses. Several alcohols and phenols were almost quantitatively converted into the corresponding tetrahydropyranyl ethers in cyclopentyl methyl ether or 2-methyltetrahydrofuran employing NH4HSO4 supported on SiO2 as a recyclable acidic catalyst. Easy work up of the reaction mixtures and the versatility of the solvents allowed further conversion of the reaction products under one-pot reaction conditions.

Crown Ether Nucleophilic Catalysts (CENCs): Agents for Enhanced Silicon Radiofluorination

New bifunctional phase transfer agents were synthesized and investigated for their abilities to promote rapid fluorination at silicon. These agents, dubbed crown ether nucleophilic catalysts (CENCs), are 18-crown-6 derivatives containing a side-arm and a potentially nucleophilic hydroxyl group. These CENCs proved efficacious in the fluorination of hindered silicon substrates, with fluorination yields dependent on the length of linker connecting the metal chelating unit to the hydroxyl group. The efficacy of these CENCs was also demonstrated for rapid radiofluorination under mild conditions for eventual application in molecular imaging with positron emission tomography (PET). The hydrolysis-resistant aryl silicon fragment is promising as a convenient synthon for labeling potential PET radiotracers.

Supported N-propylsulfamic acid onto Fe3O4 magnetic nanoparticles as a reusable and efficient nanocatalyst for the protection/deprotection of hydroxyl groups and protection of aldehydes

N-propylsulfamic acid supported onto Fe3O4 magnetic nanoparticles (MNPs-PSA) as an efficient and magnetically reusable nanocatalyst has been reported for the tetrahydropyranylation/depyranylation of a wide variety of alcohols and phenols by changing the solvent medium. Also, the protection of aldehydes as acylals using Ac2O in the presence of catalytic amount MNPs-PSA in good to high yields at room temperature under solvent-free conditions is described. After completing the reaction, the catalyst was easily separated from the reaction mixture with the assistance of an external magnetic field and reused for several consecutive runs without significant loss of their catalytic efficiency.

NOVEL LIQUID CRYSTALLINE COMPOUND AND LIQUID CRYSTAL COMPOSITION PREPARED USING THE SAME

PROBLEM TO BE SOLVED: To provide a liquid crystal compound that has a low viscosity, a high isotropic transition temperature, a high compatibility, and a high refractive index anisotropy, and is also resistant to degradation due to heat and light. SOLUTION: The present invention illustrates a naphthalene derivative represented by the general formula (1), specifically, for example, a naphthalene derivative obtained through a reaction represented by the following formula, as well as a liquid crystal composition comprising the same. Use of the liquid crystal composition comprising the liquid crystal compound makes it possible to provide a high-speed response liquid crystal display element. COPYRIGHT: (C)2016,JPOandINPIT

New Tetrahydroanthracene pyranylcyano compd. (by machine translation)

PROBLEM TO BE SOLVED: To provide a charge transport material capable of improving stability of a coating film and causing scarce side effects such as degradation of electrical properties and image deletion under high-temperature and humidity. SOLUTI