N-(3-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-(sulfamoylamino)phenoxy}-2-methylphenyl)ethanesulfonamide

Base Information

Chemical Name:N-(3-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-(sulfamoylamino)phenoxy}-2-methylphenyl)ethanesulfonamide
CAS No.:1295567-57-5
Molecular Formula:C₂₁H₂₁F₂IN₄O₅S₂
Molecular Weight:638.455
Hs Code.:

Synonyms:N-(3-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-(sulfamoylamino)phenoxy}-2-methylphenyl)ethanesulfonamide

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Chemical Property of N-(3-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-(sulfamoylamino)phenoxy}-2-methylphenyl)ethanesulfonamide

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Technology Process of N-(3-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-(sulfamoylamino)phenoxy}-2-methylphenyl)ethanesulfonamide

There total 6 articles about N-(3-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-(sulfamoylamino)phenoxy}-2-methylphenyl)ethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1295567-70-2
N-(3-{2-amino-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}-2-methylphenyl)ethanesulfonamide

: 1295567-57-5
N-(3-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-(sulfamoylamino)phenoxy}-2-methylphenyl)ethanesulfonamide

Guidance literature:: With sulphamoyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; 2,4-dichlorophenoxyacetic acid dimethylamine; at 20 ℃; for 16h;

Reference yield:

: 1295567-68-8
3-(3-amino-2-methylphenoxy)-5-fluoro-N-(2-fluoro-4-iodophenyl)-2-nitroaniline

: 1295567-57-5
N-(3-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-(sulfamoylamino)phenoxy}-2-methylphenyl)ethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 3 h / 0 °C

2: stannous chloride dihydrate / ethanol; tetrahydrofuran / 16 h / Reflux

3: N-ethyl-N,N-diisopropylamine; sulphamoyl chloride / dichloromethane; 2,4-dichlorophenoxyacetic acid dimethylamine / 16 h / 20 °C

With pyridine; stannous chloride dihydrate; sulphamoyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; 2,4-dichlorophenoxyacetic acid dimethylamine;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1295567-57-5
N-(3-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-(sulfamoylamino)phenoxy}-2-methylphenyl)ethanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 121 h / -10 - 0 °C

2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3: pyridine / 3 h / 0 °C

4: stannous chloride dihydrate / ethanol; tetrahydrofuran / 16 h / Reflux

5: N-ethyl-N,N-diisopropylamine; sulphamoyl chloride / dichloromethane; 2,4-dichlorophenoxyacetic acid dimethylamine / 16 h / 20 °C

With pyridine; stannous chloride dihydrate; sulphamoyl chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; 2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide;