N-(3-{2-amino-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}-2-methylphenyl)ethanesulfonamide

Base Information

Chemical Name:N-(3-{2-amino-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}-2-methylphenyl)ethanesulfonamide
CAS No.:1295567-70-2
Molecular Formula:C₂₁H₂₀F₂IN₃O₃S
Molecular Weight:559.375
Hs Code.:

Synonyms:N-(3-{2-amino-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}-2-methylphenyl)ethanesulfonamide

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Chemical Property of N-(3-{2-amino-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}-2-methylphenyl)ethanesulfonamide

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Technology Process of N-(3-{2-amino-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}-2-methylphenyl)ethanesulfonamide

There total 5 articles about N-(3-{2-amino-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}-2-methylphenyl)ethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1295567-69-9
N-(3-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-nitrophenoxy}-2-methylphenyl)-ethanesulfonamide

: 1295567-70-2
N-(3-{2-amino-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}-2-methylphenyl)ethanesulfonamide

Guidance literature:: N-(3-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-nitrophenoxy}-2-methylphenyl)-ethanesulfonamide; With stannous chloride dihydrate; In tetrahydrofuran; ethanol; for 16h; Reflux;

With ammonia;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1295567-70-2
N-(3-{2-amino-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}-2-methylphenyl)ethanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 121 h / -10 - 0 °C

2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3: pyridine / 3 h / 0 °C

4: stannous chloride dihydrate / ethanol; tetrahydrofuran / 16 h / Reflux

With pyridine; stannous chloride dihydrate; caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 765962-75-2
3,5-difluoro-N-(2-fluoro-4-iodophenyl)-2-nitroaniline

: 1295567-70-2
N-(3-{2-amino-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}-2-methylphenyl)ethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2: pyridine / 3 h / 0 °C

3: stannous chloride dihydrate / ethanol; tetrahydrofuran / 16 h / Reflux

With pyridine; stannous chloride dihydrate; caesium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;