(1-adamantan-2-yl-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-carbamic acid phenyl ester

Base Information

Chemical Name:(1-adamantan-2-yl-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-carbamic acid phenyl ester
CAS No.:203398-31-6
Molecular Formula:C₃₂H₃₁N₃O₄
Molecular Weight:521.616
Hs Code.:

(1-adamantan-2-yl-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1<i>H</i>-benzo[<i>b</i>][1,4]diazepin-3-yl)-carbamic acid phenyl ester

Synonyms:(1-adamantan-2-yl-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-carbamic acid phenyl ester

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Chemical Property of (1-adamantan-2-yl-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-carbamic acid phenyl ester

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Technology Process of (1-adamantan-2-yl-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-carbamic acid phenyl ester

There total 5 articles about (1-adamantan-2-yl-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-carbamic acid phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1885-14-9
phenyl chloroformate

: 151620-58-5
1-N-(adamant-2-yl)-3-amino-2,4-dioxo-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

: 203398-31-6
(1-adamantan-2-yl-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-carbamic acid phenyl ester

Guidance literature:: With pyridine; In dichloromethane; at 23 ℃; for 0.5h;
DOI:10.1021/jm990967h

Reference yield:

: 700-58-3
2-Adamantanone

: 203398-31-6
(1-adamantan-2-yl-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-carbamic acid phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄; CH₃COONa*3H₂O / acetic acid; H₂O; ethanol / 0.5 h / 23 °C

2: tetrahydrofuran / 3 h / 50 °C

3: Zn; AcOH / 3 h / 23 °C

4: pyridine / CH₂Cl₂ / 0.5 h / 23 °C

With pyridine; sodium tetrahydroborate; sodium acetate; acetic acid; zinc; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; 1: Reductive alkylation / 2: Acylation / 3: Reduction / 4: Acylation;
DOI:10.1021/jm990967h

Reference yield:

: 151386-24-2
2-(adamant-2-yl)aminodiphenylamine

: 203398-31-6
(1-adamantan-2-yl-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-carbamic acid phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 3 h / 50 °C

2: Zn; AcOH / 3 h / 23 °C

3: pyridine / CH₂Cl₂ / 0.5 h / 23 °C

With pyridine; acetic acid; zinc; In tetrahydrofuran; dichloromethane; 1: Acylation / 2: Reduction / 3: Acylation;
DOI:10.1021/jm990967h