2-[2-[4-[O-(2-methyl-2H-pyrrolo[3,4-c]quinolin-4-yl)methoxy]piperid-1-yl]ethyl]benzoic acid

Base Information

Chemical Name:2-[2-[4-[O-(2-methyl-2H-pyrrolo[3,4-c]quinolin-4-yl)methoxy]piperid-1-yl]ethyl]benzoic acid
CAS No.:1207340-21-3
Molecular Formula:C₂₇H₂₉N₃O₃
Molecular Weight:443.546
Hs Code.:

Synonyms:2-[2-[4-[O-(2-methyl-2H-pyrrolo[3,4-c]quinolin-4-yl)methoxy]piperid-1-yl]ethyl]benzoic acid

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Chemical Property of 2-[2-[4-[O-(2-methyl-2H-pyrrolo[3,4-c]quinolin-4-yl)methoxy]piperid-1-yl]ethyl]benzoic acid

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Technology Process of 2-[2-[4-[O-(2-methyl-2H-pyrrolo[3,4-c]quinolin-4-yl)methoxy]piperid-1-yl]ethyl]benzoic acid

There total 10 articles about 2-[2-[4-[O-(2-methyl-2H-pyrrolo[3,4-c]quinolin-4-yl)methoxy]piperid-1-yl]ethyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1207340-19-9
methyl 2-[2-[4-[[(2-Methyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate

: 1207340-21-3
2-[2-[4-[O-(2-methyl-2H-pyrrolo[3,4-c]quinolin-4-yl)methoxy]piperid-1-yl]ethyl]benzoic acid

Guidance literature:: methyl 2-[2-[4-[[(2-Methyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate; With sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 12h;

With acetic acid; In tetrahydrofuran; ethanol; pH=6;

Reference yield:

: 748159-52-6
2H-pyrrolo[3,4-c]quinolin-4(5H)-one

: 1207340-21-3
2-[2-[4-[O-(2-methyl-2H-pyrrolo[3,4-c]quinolin-4-yl)methoxy]piperid-1-yl]ethyl]benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N-dimethyl-formamide / 15 h / 90 °C

2.1: triethylamine; trichlorophosphate / 6 h / 120 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 10 min / 20 °C

3.2: 1 h / 146 °C

4.1: hydrogen; palladium 10% on activated carbon / acetic acid; methanol / 96 h / 20 °C / 1448.05 Torr

5.1: triethylamine; sodium iodide / butanone / 12 h / Reflux

6.1: sodium hydroxide / ethanol; tetrahydrofuran / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; sodium iodide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; acetic acid; N,N-dimethyl-formamide; butanone; paraffin oil;
DOI:10.1021/jm300573d

Reference yield:

: 1207340-30-4
4-chloro-2-methyl-2H-pyrrolo[3,4-c]quinoline

: 1207340-21-3
2-[2-[4-[O-(2-methyl-2H-pyrrolo[3,4-c]quinolin-4-yl)methoxy]piperid-1-yl]ethyl]benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 10 min / 20 °C

1.2: 1 h / 146 °C

2.1: hydrogen; palladium 10% on activated carbon / acetic acid; methanol / 96 h / 20 °C / 1448.05 Torr

3.1: triethylamine; sodium iodide / butanone / 12 h / Reflux

4.1: sodium hydroxide / ethanol; tetrahydrofuran / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; sodium iodide; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; acetic acid; N,N-dimethyl-formamide; butanone; paraffin oil;
DOI:10.1021/jm300573d