methyl 2-[2-[4-[[(2-Methyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate

Base Information

• Chemical Name: methyl 2-[2-[4-[[(2-Methyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate
• CAS No.: 1207340-19-9
• Molecular Formula: C₂₈H₃₁N₃O₃
• Molecular Weight: 457.572
• Mol file: 1207340-19-9.mol

Synonyms:methyl 2-[2-[4-[[(2-Methyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate

Chemical Property of methyl 2-[2-[4-[[(2-Methyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-[2-[4-[[(2-Methyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate

There total 6 articles about methyl 2-[2-[4-[[(2-Methyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

4-[(1-piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline (1207339-99-8) + methyl 2-(2-chloroethyl)benzoate (65787-71-5) → methyl 2-[2-[4-[[(2-Methyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate (1207340-19-9)

Guidance literature:

4-[(1-piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline; methyl 2-(2-chloroethyl)benzoate; In butanone; for 0.5h; Reflux;

With triethylamine; In butanone; for 72h; Reflux;

Reference yield:

2H-pyrrolo[3,4-c]quinolin-4(5H)-one (748159-52-6) → methyl 2-[2-[4-[[(2-Methyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate (1207340-19-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 15 h / 90 °C

2.1: triethylamine; trichlorophosphate / 6 h / 120 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 10 min / 20 °C

3.2: 1 h / 146 °C

4.1: hydrogen; palladium 10% on activated carbon / acetic acid; methanol / 96 h / 20 °C / 1448.05 Torr

5.1: triethylamine; sodium iodide / butanone / 12 h / Reflux

With palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; sodium iodide; trichlorophosphate; In methanol; acetic acid; N,N-dimethyl-formamide; butanone; paraffin oil;

DOI:10.1021/jm300573d

Reference yield:

2-nitro-benzenepropanoic acid ethyl ester (66757-87-7) → methyl 2-[2-[4-[[(2-Methyl-2H-pyrrolo[3,4-c]-4-quinolinyl)oxy]-methyl]-1-piperidinyl]ethyl]benzoate (1207340-19-9)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium hydride / diethyl ether; dimethyl sulfoxide; paraffin oil / 0.42 h / 20 °C / Inert atmosphere

2.1: iron / acetic acid / 0.75 h / 85 °C

3.1: N,N-dimethyl-formamide / 15 h / 90 °C

4.1: triethylamine; trichlorophosphate / 6 h / 120 °C

5.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 10 min / 20 °C

5.2: 1 h / 146 °C

6.1: hydrogen; palladium 10% on activated carbon / acetic acid; methanol / 96 h / 20 °C / 1448.05 Torr

7.1: triethylamine; sodium iodide / butanone / 12 h / Reflux

With palladium 10% on activated carbon; hydrogen; iron; sodium hydride; triethylamine; sodium iodide; trichlorophosphate; In methanol; diethyl ether; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; butanone; paraffin oil;

DOI:10.1021/jm300573d

upstream raw materials:

4-[(1-piperid-4-yl)methyloxy]-2-methyl-2H-pyrrolo[3,4-c]quinoline

methyl 2-(2-chloroethyl)benzoate

2-nitro-benzenepropanoic acid ethyl ester

isochromane

Downstream raw materials:

2-[2-[4-[O-(2-methyl-2H-pyrrolo[3,4-c]quinolin-4-yl)methoxy]piperid-1-yl]ethyl]benzoic acid