2-[1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Base Information

Chemical Name:2-[1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one
CAS No.:1446712-42-0
Molecular Formula:C₂₁H₂₀FN₅O
Molecular Weight:377.421
Hs Code.:

Synonyms:2-[1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Chemical Property of 2-[1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Technology Process of 2-[1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

There total 7 articles about 2-[1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426309-14-9
2-[1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

: 1446712-42-0
2-[1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In N,N-dimethyl-formamide;

Reference yield:

: 851776-29-9
1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carbonitrile

: 1446712-42-0
2-[1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: sodium methylate / methanol / 4 h / 20 °C / Inert atmosphere

2.2: 50 °C / Inert atmosphere

3.1: potassium tert-butylate / tert-butyl alcohol / 72 h / Reflux

4.1: isopentyl nitrite; cesium iodide; copper(l) iodide; iodine / 1,2-dimethoxyethane / 0.67 h / 100 °C

5.1: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide

With copper(l) iodide; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; iodine; sodium methylate; caesium carbonate; cesium iodide; isopentyl nitrite; In methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1334527-89-7
1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboximidamide

: 1446712-42-0
2-[1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tert-butyl alcohol / 72 h / Reflux

2: isopentyl nitrite; cesium iodide; copper(l) iodide; iodine / 1,2-dimethoxyethane / 0.67 h / 100 °C

3: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide

With copper(l) iodide; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; iodine; cesium iodide; isopentyl nitrite; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; tert-butyl alcohol;